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Fig. 3 | Journal of Cardiothoracic Surgery

Fig. 3

From: Xenoantigenicity of porcine decellularized valves

Fig. 3

Quantification of anti-pig IgM and IgG antibodies in sheep serum- a. There was a statistically significant increase in serum anti-pig IgM antibodies in postoperative time points (71.9 ± 12.1 μg/mL) as compared to before valve implantation (27.7 ± 1.7 μg/mL, p = 0.04). b. When comparing each postoperative time point separately to the preoperative serum levels, there was a significant increase in serum anti-pig IgM antibodies by 1 week (100.8 ± 29.6 μg/mL, p = 0.009). At 1 month, serum IgM concentrations were 40.6 ± 2.8 μg/mL (p = 0.2) and at 2 months were 74.3 ± 17.5 μg/mL (p = 0.04). c. There was a statistically significant increase in serum anti-pig IgG antibodies in postoperative time points (72.6 ± 6.0 μg/mL) as compared to before valve implantation (44.9 ± 1.5 μg/mL, p = 0.01). d. When comparing each postoperative time point separately to the preoperative serum levels, there was a significant increase in serum anti-pig IgG antibodies by 1 week (82.6 ± 14.9 μg/mL, p = 0.002). At 1 month, serum IgG concentrations were 56.9 ± 1.4 μg/mL (p = 0.3) and at 2 months were 78.3 ± 9.2 μg/mL (p = 0.02)

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