RFS | OS | |||
---|---|---|---|---|
Variables | HR (95% CI) | P value | HR (95% CI) | P value |
Age at operation, y | ||||
<70 | 1 | 1 | ||
≥70 | 1.12 (0.56–2.14) | 0.762 | 2.31 (1.12–5.13) | 0.031 |
Gender | ||||
Female | 1 | 1 | ||
Male | 1.13 (0.54–2.28) | 0.668 | 1.02 (0.78–1.52) | 0.869 |
Smoking habit | ||||
Never smoker | 1 | 1 | ||
Ever smoker | 1.22 (0.88–1.72) | 0.281 | 1.21 (0.86–1.82) | 0.225 |
Serum CEA, ng/ml | ||||
≤5 | 1 | 1 | ||
>5 | 2.11 (1.03–4.12) | 0.049 | 2.42 (1.31–5.46) | 0.019 |
Extent of pulmonary resection | ||||
Segmentectomy | 1 | 1 | ||
Lobectomy or more | 0.75 (0.56–1.21) | 0.221 | 0.81 (0.55–1.26) | 0.231 |
Tumor location | ||||
Central | 1 | 1 | ||
Non-central | 0.94 (0.44–1.86) | 0.852 | 0.58 (0.79–4.22) | 0.586 |
SUVmax of primary tumor | ||||
≤2.3 | 1 | 1 | ||
>2.3 | 5.89 (3.45–14.2) | <0.001 | 3.89 (1.64–9.01) | 0.001 |
D-dimer, μg/ml | ||||
≤1.0 | 1 | 1 | ||
>1.0 | 2.62 (1.41–5.61) | 0.019 | 2.67 (1.23–5.12) | 0.021 |
Tumor size, cm | ||||
≤3 | 1 | 1 | ||
>3 | 1.32 (0.64–2.72) | 0.483 | 1.16 (0.54–2.76) | 0.688 |
Histological type | ||||
AD | 1 | 1 | ||
Others | 1.33 (0.64–2.76) | 0.486 | 1.35 (0.64–2.81) | 0.479 |
Grade | ||||
1 | 1 | 1 | ||
2 / 3 / 4 | 1.33 (0.61–2.79) | 0.438 | 1.41 (0.68–2.82) | 0.439 |
Pleural invasion | ||||
Absent | 1 | 1 | ||
Present | 2.42 (1.06–5.52) | 0.038 | 1.95 (0.76–5.01) | 0.181 |
Pathological stage | ||||
Stage I | 1 | 1 | ||
Stage II/III | 5.61 (3.22–9.12) | <0.001 | 3.91 (1.65–8.98) | 0.001 |