Fig. 1

Serum creatine kinase levels are displayed with respect to the duration of hospitalization. The upper limit of normal (200 U/L) is indicated by the dashed horizontal line, while the onset of an intervention is indicated by a dashed vertical line. High-dose prednisone (1 mg/kg/d) was started on hospital day 2; methotrexate (MTX, 7.5 mg/week) and intravenous immunoglobulin (IVIG, 2 g/kg/mo) began on hospital day 11; and right middle lobectomy and mediastinal lymph node dissection took place on hospital day 16. Not shown are escalations of the methotrexate dose to 10 mg/week (hospital day 18) and 15 mg/week (hospital day 25), as well as discharge and commencement of the steroid taper, which coincided on hospital day 29