SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma

Table 3 Results of univariate log-rank analysis of prognostic factors for overall survival and disease-free survival in 155 patients with esophageal squamous cell carcinoma receiving esophagectomy

Factors	No. of patients	Overall survival (OS)		Disease-free survival (DFS)
Factors	No. of patients	5-yr OS rate (%)	P value	5-yr DFS rate (%)	P value
Age
< 55y/o	69	54%	0.19	48%	0.10
≧55y/o	86	37%		29%
Location
U + M	82	45%	0.84	35%	0.46
L	73	44%		40%
T classification
T1 + 2	79	64%	< 0.001^a	52%	< 0.001^a
T3 + 4	76	24%		22%
N classification
N0	106	56%	< 0.001^a	47%	< 0.001^a
N1 + 2 + 3	49	20%		16%
7^th AJCC stage
I + II	112	55%	< 0.001^a	46%	< 0.001^a
III + IV	43	16%		16%
Histological grading
Grade 1 + 2	124	51%	0.001^a	43%	0.002^a
Grade 3	31	19%		16%
Surgical margin
Negative	135	47%	0.023^a	39%	0.046^a
Positive	20	25%		25%
SIRT1 expression
Low expression	78	55%	0.004^a	49%	0.004^a
Overexpression	77	34%		26%

AJCC American Joint Committee on Cancer, SIRT1 Sirtuin1 ^aStatistically significant

ISSN: 1749-8090