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Table 3 Results of univariate log-rank analysis of prognostic factors for overall survival and disease-free survival in 155 patients with esophageal squamous cell carcinoma receiving esophagectomy

From: SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma

Factors No. of patients Overall survival (OS) Disease-free survival (DFS)
5-yr OS rate (%) P value 5-yr DFS rate (%) P value
Age
  < 55y/o 69 54% 0.19 48% 0.10
55y/o 86 37%   29%  
Location
 U + M 82 45% 0.84 35% 0.46
 L 73 44%   40%  
T classification
 T1 + 2 79 64% < 0.001a 52% < 0.001a
 T3 + 4 76 24%   22%  
N classification
 N0 106 56% < 0.001a 47% < 0.001a
 N1 + 2 + 3 49 20%   16%  
7th AJCC stage
 I + II 112 55% < 0.001a 46% < 0.001a
 III + IV 43 16%   16%  
Histological grading
 Grade 1 + 2 124 51% 0.001a 43% 0.002a
 Grade 3 31 19%   16%  
Surgical margin
 Negative 135 47% 0.023a 39% 0.046a
 Positive 20 25%   25%  
SIRT1 expression
 Low expression 78 55% 0.004a 49% 0.004a
 Overexpression 77 34%   26%  
  1. AJCC American Joint Committee on Cancer, SIRT1 Sirtuin1 aStatistically significant