Fig. 5

Histologic features in in cardiac allograft exposed with Thrombomodulin (TM) or normal saline. a, b Results of hematoxylin-eosin staining of myocardium and coronary arteries in cardiac allografts obtained 2 weeks after transplantation from TM-exposed (a) or untreated recipients (b) (original magnification of bigger panels and smaller panels, × 20 and × 40, respectively). c The extent of mononuclear cell infiltration. Each section was assessed by grading with a semi-quantitative scale for the amount of mononuclear cell infiltration (0, no infiltration; 1, faint and limited infiltration; 2, moderate infiltration; 3, severe infiltration). nTx, untreated . ###p < 0.001 compared with untreated group