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Table 2 Proportion of patients meeting endpoints according to randomized left atrial appendage closure, stratified by use of anti-coagulants

From: Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study

Endpoint Not closed (n = 86) Closed (n = 101) Hazard ratio P-value
Primary eventsa 14 (16.3%) 5 (5.0%) 0.3 [95% CI: 0.1–0.8] 0.0168
Clinical strokeb 8 (10.0%) 3 (3.0) 0.3 [95% CI: 0.1–1.1] 0.0763
Death 12 (14.0%) 12 (11.9%) 0.8 [95% CI: 0.43–1.9] 0.6562
  1. aDefined as first of postoperative symptomatic ischemic stroke, transient ischemic attack or imaging evidence of new silent infarct
  2. bExcluding 8 patients that were classified as primary events due to imaging findings