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Table 2 Proportion of patients meeting endpoints according to randomized left atrial appendage closure, stratified by use of anti-coagulants

From: Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study

Endpoint

Not closed (n = 86)

Closed (n = 101)

Hazard ratio

P-value

Primary eventsa

14 (16.3%)

5 (5.0%)

0.3 [95% CI: 0.1–0.8]

0.0168

Clinical strokeb

8 (10.0%)

3 (3.0)

0.3 [95% CI: 0.1–1.1]

0.0763

Death

12 (14.0%)

12 (11.9%)

0.8 [95% CI: 0.43–1.9]

0.6562

  1. aDefined as first of postoperative symptomatic ischemic stroke, transient ischemic attack or imaging evidence of new silent infarct
  2. bExcluding 8 patients that were classified as primary events due to imaging findings
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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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