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Table 3 Proportion of patients meeting endpoints according to per-protocol left atrial appendage closure stratified by use of anti-coagulants

From: Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study

Endpoint Not closed
(n = 77)
Closed
(n = 64)
Hazard ratio P-value
Primary eventsa 14 (18.2%) 4 (6.3%) 0.3 [95% CI: 0.1–0.9] 0.0237
Clinical strokeb 8 (11.3%) 2 (3.2%) 0.3 [95% CI: 0.1–1.3] 0.0907
Death 10 (13.0%) 6 (9.4%) 0.7 [95% CI: 0.3–2.3] 0.7067
  1. aDefined as first of postoperative symptomatic ischemic stroke, transient ischemic attack or imaging evidence of new silent infarct
  2. bExcluding 8 patients that were classified as primary events due to imaging findings