Skip to main content

Table 3 Proportion of patients meeting endpoints according to per-protocol left atrial appendage closure stratified by use of anti-coagulants

From: Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study

Endpoint

Not closed

(n = 77)

Closed

(n = 64)

Hazard ratio

P-value

Primary eventsa

14 (18.2%)

4 (6.3%)

0.3 [95% CI: 0.1–0.9]

0.0237

Clinical strokeb

8 (11.3%)

2 (3.2%)

0.3 [95% CI: 0.1–1.3]

0.0907

Death

10 (13.0%)

6 (9.4%)

0.7 [95% CI: 0.3–2.3]

0.7067

  1. aDefined as first of postoperative symptomatic ischemic stroke, transient ischemic attack or imaging evidence of new silent infarct
  2. bExcluding 8 patients that were classified as primary events due to imaging findings