TY - JOUR AU - Zeilmaker-Roest, Gerda A. AU - van Saet, Annewil AU - van Rosmalen, Joost AU - Bahmany, Soma AU - van Dijk, Antony AU - Wildschut, Enno D. AU - Tibboel, Dick AU - Bogers, Ad J. J. C. PY - 2018 DA - 2018/06/08 TI - Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery JO - Journal of Cardiothoracic Surgery SP - 64 VL - 13 IS - 1 AB - Use of donor blood in congenital cardiac surgery increases the risk for post-operative morbidity and mortality. To reduce the need for allogenic blood transfusion a technique for peri-operative mechanical red cell salvage is applied. Blood from the operation site is collected in a reservoir, processed, passed through a lipophilic filter and returned to the patient. Influence of this cellsaver system on coagulation, fibrinolysis and inflammatory markers is known. To our knowledge no studies have been performed on the effects of autotransfusion on drug concentrations. A clinically relevant drug dose could potentially be returned to the patient through the auto-transfused blood, leading to unwanted drug reactions post-operatively. We aimed to measure drug concentrations in blood salvaged from the operation site and in the auto-transfused blood to determine if a clinically relevant drug dose is returned to the patient. SN - 1749-8090 UR - https://doi.org/10.1186/s13019-018-0747-0 DO - 10.1186/s13019-018-0747-0 ID - Zeilmaker-Roest2018 ER -