Table 2 Drug concentration per sample site
Drug | Patients (n) | Concentration (median, IQR) | Ratio reservoir vs autotransfused blood in % (median, IQR) | |||
|---|---|---|---|---|---|---|
Reservoir | After processing, before filter | Auto-transfused blood | Waste fluid | |||
Sufentanil (mcg/L) | 18 | 0.27 (0.18–0.35) | 0.10 (0.09–0.12) | 0.10 (0.09–0.10) | 0.13 (0.10–0.16) | 34 (27–50) |
Midazolam (mcg/L) | 18 | 192.69 (49.06–316.42) | 18.68 (4.91–29.88) | 11.87(7.16–20.16) | 56.48 (17.25–75.18) | 6 (4–10) |
1-hydroxy-midazolam (mcg/L) | 18 | 36.56 (9.45–62.74) | 6.23 (4.39–11.52) | 4.67 (3.82–5.95) | 3.51 (2.72–3.84) | 11 (7–29) |
Midazolam glucuronide (mcg/L) | 18 | 348.21 (236.63–592.21) | 36.41 (15.83–57.13) | 29.22 (21.40–41.82) | 114.07 (75.33–189.71) | 6 (4–8) |
Cefazolin (mg/L) | 18 | 228.44 (118.47–295.85) | 10.50 (6.63–17.47) | 8.70 (5.13–11.44) | 59.34 (40.68–77.80) | 5 (2–6) |
Propofol (mg/L) | 6 | 0.65 (0.21–1.86) | 0 (0–0)* | 0 (0–0)* | 0.18 (0.25–0.11) | 0 (0–0) |