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Table 2 Drug concentration per sample site

From: Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery

Drug Patients (n) Concentration (median, IQR) Ratio reservoir vs autotransfused blood in % (median, IQR)
Reservoir After processing, before filter Auto-transfused blood Waste fluid
Sufentanil (mcg/L) 18 0.27 (0.18–0.35) 0.10 (0.09–0.12) 0.10 (0.09–0.10) 0.13 (0.10–0.16) 34 (27–50)
Midazolam (mcg/L) 18 192.69 (49.06–316.42) 18.68 (4.91–29.88) 11.87(7.16–20.16) 56.48 (17.25–75.18) 6 (4–10)
1-hydroxy-midazolam (mcg/L) 18 36.56 (9.45–62.74) 6.23 (4.39–11.52) 4.67 (3.82–5.95) 3.51 (2.72–3.84) 11 (7–29)
Midazolam glucuronide (mcg/L) 18 348.21 (236.63–592.21) 36.41 (15.83–57.13) 29.22 (21.40–41.82) 114.07 (75.33–189.71) 6 (4–8)
Cefazolin (mg/L) 18 228.44 (118.47–295.85) 10.50 (6.63–17.47) 8.70 (5.13–11.44) 59.34 (40.68–77.80) 5 (2–6)
Propofol (mg/L) 6 0.65 (0.21–1.86) 0 (0–0)* 0 (0–0)* 0.18 (0.25–0.11) 0 (0–0)
  1. IQR Interquartile range, L Litre, Mcg Microgram, mg Milligram, n.a. Not applicable *Drug concentrations for propofol were not measurable after autotransfusion and were treated as zero in the analysis