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Table 3 Candidate plasma biomarkers for predicting risk of aneurysm in BAV patients with non-aneurysmal aortas

From: Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease

Protein Name Uniprot ID Function Up- or downregulateda
DNA-dependent protein kinase catalytic subunit P78527 Serine/threonine-protein kinase, molecular sensor for DNA damage. Up
Lumican P51884 Collagen fibril organization, epithelial cell migration and tissue repair. Down
Tetranectin P05452 Binds plasminogen and isolated kringle 4. Packaging molecules for exocytosis. Down
Gelsolin P06396 Key regulator of actin filament assembly and disassembly. Down
Cartilage acidic protein 1 Q9NQ79 Upregulated by BMP4 in mesenchymal stem cells undergoing chondrogenic differentiation. Down
Matrin-3 P43243 Transcription and interaction with other nuclear matrix proteins to form the internal fibrogranular network. N/A
Glucose-6-phosphate isomerase P06744 Glycolytic enzyme and angiogenic factor (AMF) that stimulates endothelial cell motility. N/A
Coactosin-like protein Q14019 Binds to F-actin in a calcium-independent manner. N/A
Peptidyl-prolyl cis-trans isomerase A P62937 Accelerates the folding of proteins. N/A
Myeloperoxidase P05164 Produces hypochlorous acid (HOCl) used by the neutrophils to kill bacteria and other pathogens. N/A
Golgin subfamily B member 1 Q14789 Forms intercisternal cross-bridges of the Golgi complex. N/A
2′-deoxynucleoside 5′-phosphate N-hydrolase 1 O43598 Catalyses cleavage of the N-glycosidic bond of deoxyribonucleoside 5′-monophosphates. N/A
  1. Biomarker name, Uniprot ID, function and direction of change are given
  2. aDirection of change in plasma biomarker that indicates a patient may be at risk of future aortopathy. ‘N/A’ (not applicable) indicates that presence of the protein in plasma alone may indicate risk of future aortopathy