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Table 3 Multivariate analysis of factors predicting recurrence-free survival

From: Neutrophil-lymphocyte ratio predicts recurrence in patients with resected stage 1 non-small cell lung cancer

Factors Univariate
(P-value)
Multivariate
(P-value)
Risk ratio 95% CI
Sex (male vs. female) 0.001 0.118
Age (≥70 years) < 0.001 < 0.001 2.20 1.38–3.53
PS (2 vs. 0–1) 0.254
Smoking 0.005 0.183
NLR(> 1.5) 0.009 0.011 2.03 1.17–3.79
Predicted post PFTa 0.211
Histology (other vs adenocarcinoma) 0.123 0.090
Differentiation (m/p vs. well) 0.004 0.038 1.77 1.03–3.18
Lymph-vascular invasion < 0.001 < 0.001 2.31 1.47–3.66
Pathological stage (IB vs. IA) < 0.001 0.003 2.09 1.27–3.48
Postoperative complication 0.368
Preoperative comorbidities     
Hypertension 0.846
Diabetes mellitus 0.797
eGFR (< 70 mL/min/1.73 m2) 0.107 0.647
Child–Pugh classification (B or C) 0.246
Cardiac disease 0.389
Cerebral disease 0.008 0.367
Any prior tumors 0.191 0.070
  1. aPredicted postoperative values of FEV1.0 or DLCO < 40% is defined as high-risk for PFTs
  2. PS performance status, NLR neutrophil-lymphocyte ratio, PFT pulmonary function test, m/p moderate or poor, eGFR estimated glomerular filtration rate