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Table 3 Multivariate analysis of factors predicting recurrence-free survival

From: Neutrophil-lymphocyte ratio predicts recurrence in patients with resected stage 1 non-small cell lung cancer

Factors

Univariate

(P-value)

Multivariate

(P-value)

Risk ratio

95% CI

Sex (male vs. female)

0.001

0.118

Age (≥70 years)

< 0.001

< 0.001

2.20

1.38–3.53

PS (2 vs. 0–1)

0.254

Smoking

0.005

0.183

NLR(> 1.5)

0.009

0.011

2.03

1.17–3.79

Predicted post PFTa

0.211

Histology (other vs adenocarcinoma)

0.123

0.090

Differentiation (m/p vs. well)

0.004

0.038

1.77

1.03–3.18

Lymph-vascular invasion

< 0.001

< 0.001

2.31

1.47–3.66

Pathological stage (IB vs. IA)

< 0.001

0.003

2.09

1.27–3.48

Postoperative complication

0.368

Preoperative comorbidities

    

Hypertension

0.846

Diabetes mellitus

0.797

eGFR (< 70 mL/min/1.73 m2)

0.107

0.647

Child–Pugh classification (B or C)

0.246

Cardiac disease

0.389

Cerebral disease

0.008

0.367

Any prior tumors

0.191

0.070

  1. aPredicted postoperative values of FEV1.0 or DLCO < 40% is defined as high-risk for PFTs
  2. PS performance status, NLR neutrophil-lymphocyte ratio, PFT pulmonary function test, m/p moderate or poor, eGFR estimated glomerular filtration rate