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Table 1 Clinical and utility data used in the model for sNPWT compared to standard care in patients following CABG surgery. The table shows the baseline data, effectiveness of sNPWT and health related quality of life (utility) data that was applied in the model

From: Cost-effectiveness analysis of single use negative pressure wound therapy dressings (sNPWT) compared to standard of care in reducing surgical site complications (SSC) in patients undergoing coronary artery bypass grafting surgery

Outcome

Mean

Number of patients

Events

Distribution

Reference

Baseline SSC rate

0.048

2621

127

Beta

Cristofolini [16]

Mortality with SSC

0.017

118

2

Beta

ibid

Mortality without SSC

0.007

2503

18

Beta

Readmission SSC

0.034

118

4

Beta

Readmission No SSC

0.000

2503

1

Beta

Revision SSC

0.068

118

8

Beta

Revision No SSC

0.005

2503

12

Beta

All-cause mortality

0.003

   

[18]

Multiplier for revision mortality

1.300

   

Wu [19]

Length of stay data

 Length of stay with surgical site complications

Mean

Lower CI

Upper CI

  

 Intensive care unit

15.2

1

87.2

Log normal

Cristofolini [16]

 Intermediate care

4.8

0.5

25.2

Log normal

 General ward

22.3

0.5

68.4

Log normal

Length of stay without surgical site complications

 Intensive care unit

3.8

1

26

Log normal

Cristofolini [16]

 Intermediate care

2.4

0.5

10

Log normal

 General ward

8.3

0.5

19

Log normal

Utility data used in the model

 Parameter

Mean

Alpha

Beta

Distribution

Source

 Disutility with SSI

0.2

8

41

Beta

Tuffaha [13]

 Utility with no SSI

0.91

185

18

Beta

Effectiveness data (Odds ratio and 95% CI)

 Outcome

Mean

Lower CI

Upper CI

Distribution

Source

 Odds ratio for SSC

0.220

0.060

0.810

Log normal

Witt-Majchrzak [17]

 Reduction in LOS (days)

0.500

0.020

0.70

Log normal

Strugala [14]

  1. Abbreviations: sNPWT single use negative pressure wound therapy, SSC surgical site complications, CI confidence interval, LOS length of stay