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Table 1 Low dose inhibitors (Comparison of low dose BTX-A and papaverine)

From: Relaxation matters: comparison of in-vitro vasodilatory role of botulinum toxin-A and papaverine in human radial artery grafts

Vasoconstrictor Inhibitor agent 0th hour 2nd hour
5-HT 10− 6 M BTX-A 10− 8 M 87.3 ± 11.1% 80.0 ± 7.1%
Pap 10− 6 M 35.2 ± 10.1% * 51.9 ± 6.3% *
ET-1 10− 8 M BTX-A 10− 8 M 54.3 ± 12.3% 46.5 ± 10.4%
Pap 10− 6 M 61.0 ± 14.2% 84.2 ± 23.1% *
  1. 5-HT: Serotonin, BTX-A: Botulium toxin A, ET-1: Endothelin 1, Pap: Papaverine. Results are % of vasoconstrictor (5-HT or ET-1) elicited maximal control contractions (Mean ± SD). *p < 0.05 compared to same hour BTX-A 10− 8 M (boldface entries)