Table 3 Univariate and multivariate Cox proportional hazard regression analysis of the clinicopathological parameters of all patients (n = 231)

 Age (< 70)

0.628

0.366–1.077

0.091

 Sex (Female)

0.49

0.368–0.651

< 0.001

0.459

0.177–1.192

0.11

 pStage (II–IV)

3.291

2.061–5.235

< 0.001

2.344

1.4–3.924

0.001

 Smoking history (Yes)

3.85

2.257–6.568

< 0.001

1.346

0.533–3.403

0.53

 Histological type (non-adeno)

3.272

2.078–5.153

< 0.001

1.327

0.776–2.271

0.302

 Solid TDT (< 400 d)

3.034

1.682–5.473

< 0.001

2.093

1.111–3.944

0.022

 Age (< 70)

1.331

0.786–2.254

0.287

 Sex (Female)

0.639

0.494–0.827

0.001

0.318

0.128–0.788

0.013

 pStage (II–IV)

4.067

2.537–6.52

0.001

2.846

1.662–4.874

< 0.001

 Smoking history (Yes)

2.161

1.325–3.525

0.002

0.489

0.197–1.211

0.122

 Histological type (non-adeno)

2.897

1.811–4.633

< 0.001

1.617

0.894–2.922

0.112

 Solid TDT (< 400 d)

3.152

1.673–5.939

< 0.001

2.099

1.063–4.144

0.033