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Table 3 Univariate analysis of possible prognostic factors in node-negative patients (n = 101)

From: Pattern of recurrence and prognostic factors in patients with pT1-3 N0 esophageal squamous cell carcinoma after surgery: analysis of a single center experience

Possible prognostic factor OR 95% CI P-value
Age (< 64 yr. vs ≥ 64 yr)b 0.838 0.337–2.086 0.705
p-T stage (T1 vs T2–3) 0.569 0.188–1.721 0.318
p-TNM stage (I vs II) 0.642 0.258–1.602 0.342
TLN (< 23 vs ≥ 23)b 1.956 0.766–4.997 0.161
Sex (male vs female) 6.193 0.826–46.428 0.076
Tumor location (UT vs MT/LT + EGJ) 3.809 1.353–10.719 0.011*
Lymphovascular invasion (+ vs -) 7.471 2.428–22.990 < 0.001*
Perineural invasion (+ vs -) 2.365 0.848–6.591 0.100
CEA (≥ 5 μg/ml vs < 5 μg/ml)a 5.545 1.787–17.203 0.003*
Tumor grade (poor vs well + moderate) 3.577 1.335–9.581 0.011*
SCC (≥1.5 μg/ml vs < 1.5 μg/ml) a 0.383 0.088–1.659 0.199
Surgical approach (left vs right) 0.581 0.226–1.499 0.262
Smoking history (yes vs no) 0.935 0.375–2.329 0.886
Postoperative complications (yes vs no) 1.145 0.435–3.015 0.784
BMI (< 23 vs ≥ 23)b 1.004 0.404–2.497 0.993
Operation time (< 445 min vs ≥ 445 min)b 0.951 0.377–2.397 0.915
Blood loss (< 200 ml vs ≥ 200 ml)b 0.493 0.143–1.699 0.262
Tumor size (< 3.0 cm vs ≥ 3.0 cm)b 0.445 0.169–1.173 0.101
  1. BMI body mass index, CI confidence interval, CEA serum carcinoembryonic antigen level, EGJ gastroesophageal junction, LT lower thoracic, MT middle thoracic, OR odds ratio, S-SCC serum squamous cell carcinoma antigen level, TNM the AJCC Tumor Node Metastasis Classification of Carcinoma of the Esophagus and Esophagogastric Junction (8th Edition), TLN total number of removed lymph nodes, UT upper thoracic
  2. athe upper limit of the clinical reference value was used as the cutoff value
  3. bthe median was used as the cutoff value
  4. *: P-value < 0.05