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Table 3 Univariate analysis of possible prognostic factors in node-negative patients (n = 101)

From: Pattern of recurrence and prognostic factors in patients with pT1-3 N0 esophageal squamous cell carcinoma after surgery: analysis of a single center experience

Possible prognostic factor

OR

95% CI

P-value

Age (< 64 yr. vs ≥ 64 yr)b

0.838

0.337–2.086

0.705

p-T stage (T1 vs T2–3)

0.569

0.188–1.721

0.318

p-TNM stage (I vs II)

0.642

0.258–1.602

0.342

TLN (< 23 vs ≥ 23)b

1.956

0.766–4.997

0.161

Sex (male vs female)

6.193

0.826–46.428

0.076

Tumor location (UT vs MT/LT + EGJ)

3.809

1.353–10.719

0.011*

Lymphovascular invasion (+ vs -)

7.471

2.428–22.990

< 0.001*

Perineural invasion (+ vs -)

2.365

0.848–6.591

0.100

CEA (≥ 5 μg/ml vs < 5 μg/ml)a

5.545

1.787–17.203

0.003*

Tumor grade (poor vs well + moderate)

3.577

1.335–9.581

0.011*

SCC (≥1.5 μg/ml vs < 1.5 μg/ml) a

0.383

0.088–1.659

0.199

Surgical approach (left vs right)

0.581

0.226–1.499

0.262

Smoking history (yes vs no)

0.935

0.375–2.329

0.886

Postoperative complications (yes vs no)

1.145

0.435–3.015

0.784

BMI (< 23 vs ≥ 23)b

1.004

0.404–2.497

0.993

Operation time (< 445 min vs ≥ 445 min)b

0.951

0.377–2.397

0.915

Blood loss (< 200 ml vs ≥ 200 ml)b

0.493

0.143–1.699

0.262

Tumor size (< 3.0 cm vs ≥ 3.0 cm)b

0.445

0.169–1.173

0.101

  1. BMI body mass index, CI confidence interval, CEA serum carcinoembryonic antigen level, EGJ gastroesophageal junction, LT lower thoracic, MT middle thoracic, OR odds ratio, S-SCC serum squamous cell carcinoma antigen level, TNM the AJCC Tumor Node Metastasis Classification of Carcinoma of the Esophagus and Esophagogastric Junction (8th Edition), TLN total number of removed lymph nodes, UT upper thoracic
  2. athe upper limit of the clinical reference value was used as the cutoff value
  3. bthe median was used as the cutoff value
  4. *: P-value < 0.05