Fig. 1

Experimental strategy for establishment of the mouse model of pericardial adhesion. To screen for inducers of pericardial adhesion, several compounds or blood samples were injected into the pericardial cavity using a one-shot injection method. Assessment of the induction of pericardial adhesion was carried out by micro-computed tomography imaging. Optimal condition (dosages and treatment durations) were evaluated, and adhesion tissues were evaluated by histological analysis. Finally, the pericardial adhesion tissues that formed in mice were compared with those of humans by histological analysis