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Table 2 Estimated changes in ROTEM values and fibrinogen levels after four waves of blood product transfusion (intervention)

From: Interval changes in ROTEM values during cardiopulmonary bypass in pediatric cardiac surgery patients

Outcome Intervention Estimates pb
Na Before (95% CI) After (95% CI) Change (95% CI)
HEPTEM CT (sec) Intervention I 266 206.5 (194.2, 218.9) 278.4 (264.6, 292.2) 71.9 (59.8, 83.9) < 0.001
Intervention II 206 276.2 (264.9, 287.4) 217.0 (199.7, 234.4) −59.1 (−79.3, −39.0) < 0.001
Intervention III 219 223.7 (204.0, 243.4) 334.4 (301.1, 367.8) 110.8 (77.7, 143.8) < 0.001
Intervention IV 189 335.6 (248.1, 423.1) 265.1 (182.5, 347.7) −70.5 (−102.8, −38.2) < 0.001
HEPTEM MCF (mm) Intervention I 266 60.6 (58.5, 62.7) 37.9 (35.6, 40.2) −22.7 (−24.2, −21.2) < 0.001
Intervention II 205 38.6 (37.0, 40.2) 55.0 (51.2, 58.8) 16.4 (12.4, 20.4) < 0.001
Intervention III 217 54.9 (51.2, 58.5) 53.7 (50.4, 57.0) −1.2 (−3.7, 1.4) 0.380
Intervention IV 188 54.8 (48.1, 61.5) 58.0 (51.5, 64.5) 3.3 (1.1, 5.4) 0.003
FIBTEM MCF (mm) Intervention I 255 15.0 (13.0, 16.9) 4.9 (3.1, 6.7) −10.1 (−11.0, −9.2) < 0.001
Intervention II 196 5.1 (4.5, 5.6) 7.9 (6.8, 9.0) 2.9 (1.8, 4.0) < 0.001
Intervention III 219 7.9 (6.7, 9.1) 10.5 (9.4, 11.7) 2.7 (2.0, 3.4) < 0.001
Intervention IV 190 10.6 (9.1, 12.1) 11.2 (9.8, 12.7) 0.6 (−0.3, 1.6) 0.197
HEPTEM α (°) Intervention I 265 75.2 (73.1, 77.1) 49.3 (45.5, 53.1) −25.9 (−30.8, −21.0) < 0.001
Intervention II 204 51.2 (48.7, 53.7) 73.3 (69.6, 76.5) 22.1 (16.8, 27.4) < 0.001
Intervention III 217 71.3 (67.4, 74.7) 65.7 (63.0, 68.2) −5.6 (−8.5, −2.7) < 0.001
Intervention IV 188 66.1 (59.8, 71.6) 69.6 (63.8, 74.3) 3.4 (1.0, 5.9) 0.005
  1. aN was number of observations used for each model. All the models were controlled for age groups, whether each of the interventions was received, as well as interaction between age groups and before or after the intervention
  2. bGeneralized linear mixed model using beta distribution was applied to predict α (°), while generalized estimation equation was used for other outcomes. Estimates were predicted marginal means
  3. CI confidence interval, CT clotting time, MCF maximum clot firmness
  4. p values in bold represent statistical significance