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Table 2 The demographics and perioperative data of study patients(n = 123)

From: Preoperative platelet count, preoperative hemoglobin concentration and deep hypothermic circulatory arrest duration are risk factors for acute kidney injury after pulmonary endarterectomy: a retrospective cohort study

Variables

No AKI

Stage

P Value*

1

2

3

Patient population

68

38

10

7

 

Demographic data

 Age (y)

45.0 (32.5, 56.0)

52.0 (41.5, 54.0)

55.5(44.0, 64.3)

51.0 (25.0, 60.0)

0.063

 Male sex (%)

47(69.1%)

20(52.6%)

8(80%)

7(100%)

0.798

 BMI (kg/m2)

23.5 (21.1, 26.0)

22.6 (20.0, 25.6)

22.2 (21.0, 23.6)

23.7 (19.6, 25.3)

0.222

Medical history

 Diabetes (%)

3(4.4%)

1(2.6%)

0

0

0.768

 Hypertension (%)

13(19.1%)

4(10.5%)

2(20.0%)

1(14.3%)

0.340

 CAD (%)

7(10.3%)

2(5.3%)

1(10.0%)

1(14.3%)

0.559

 Smoking (%)

16(23.5%)

9(23.7%)

3(30.0%)

3(42.9%)

0.634

Risk factors for CTEPH

 Deep venous embolism (%)

28(41.2%)

16(42.1%)

4(40.0%)

1(14.3%)

0.736

 Acute pulmonary embolism (%)

14(20.6%)

9(23.7%)

3(30%)

0

0.868

 History of acute thrombolysis (%)

12(17.6%)

4(10.5%)

1(10.0%)

0

0.172

 Anti-phospholipid syndrome (%)

6(8.8%)

1(2.6%)

1(10.0%)

1(14.3%)

0.715

Baseline (Preoperative) renal function

 Preoperative serum creatinine (mg/dL)

0.92 (0.82, 1.10)

0.86 (0.76, 1.04)

1.01 (0.87, 1.08)

1.13 (1.01,1.20)

0.584

 Renal insufficiency (%)

7(10.3%)

2(5.3%)

1(10.0%)

2(28.6%)

0.823

Preoperative cardiac status

 Anteroposterior diameter of right ventricular (mm)

29.0 (25.5, 37.0)

31.0 (26.5, 39.0)

36.0 (25.0, 46.0)

46.0 (28.0, 58.0)

0.066

 Internal diameter of major pulmonary artery (mm)

29.0 (25.0, 31.8)

30.0 (24.5, 34.5)

31.5 (23.5, 37.5)

33.0 (31.0, 45.0)

0.031

 Left ventricular ejection fraction (%)

65 (60, 71)

67 (61, 73)

73 (62, 75)

67 (55, 70)

0.255

 NYHA class III

45(66.2%)

27(71.1%)

8(80.0%)

6(85.7%)

0.161

 NYHA class IV

1(1.5%)

2(5.3%)

0

1(14.3%)

0.467

Right heart catheterization Data

 Mean pulmonary arterial pressure (mmHg)

47.0 (40.0, 60.0)

48.5 (39.8,53.5)

51.0 (47.5, 62.5)

55.0 (46.8, 62.3)

0.909

 Pulmonary vascular resistance (Wood U)

8.3 (5.4, 13.4)

7.6 (6.2, 10.1)

10.2 (6.5, 15.4)

6.8 (5.5, 14.1)

0.901

 Cardiac output (L min−1)

5.0 (3.8, 5.7)

4.5 (3.9, 5.3)

3.4 (3.2, 5.3)

4.5 (3.8, 6.3)

0.125

Laboratory tests

 Preoperative platelet count (109/L)

212 (173, 241)

174 (127, 219)

165 (133, 208)

194 (105, 202)

0.002

 Preexisting thrombocytopenia (platelet count< 150,109/L) (%)

11(16.2%)

9(23.7%)

3(30%)

3(42.9%)

0.134

 Preoperative hemoglobin (g/L)

149 (137, 157)

139 (113, 151)

153 (127, 158)

155 (138, 163)

0.065

 Preexisting anemia (%)

2(2.9%)

8(21.1%)

1(10%)

1(14.3%)

0.005

intraoperative blood product use (%)

 Red blood cells

1(1.5%)

0

0

1(14.3%)

0.008

 Fresh frozen plasma

4(5.9%)

2(5.3%)

2(20%)

1(14.3%)

0.052

 Platelets

2(2.9%)

4(10.5%)

3(30%)

1(14.3%)

0.007

Surgical details

 Procedure time (min)

325 (296, 346)

332 (301, 364)

373 (313, 384)

383 (335, 468)

0.09

 CPB duration (min)

222 (187, 243)

229 (190, 256)

249 (213, 275)

252 (236, 299)

0.045

 Aortic cross-clamp time (min)

104 (89, 124)

117 (86, 131)

100 (84, 135)

136 (113, 149)

0.145

 DHCA duration (min)

37 (20, 45)

41 (31, 48)

36 (27, 49)

47 (36, 58)

0.014

 Lowest rectal temperature (°C)

19.6 (18.9, 20.6)

19.1 (18.7, 20.0)

19.4 (18.4, 19.9)

19.2 (18.7, 20.2)

0.074

 Lowest nasopharyngeal temperature (°C)

18.0 (17.7,18.6)

18.1 (17.6,18.5)

18.2 (18.0,19.0)

18.0 (17.7,18.7)

0.555

Outcomes (%)

 RRT

0

0

0

4(57.1%)

0.08

 ECMO

1(1.5%)

0

0

2(28.6%)

0.852

 Delirium

6(8.8%)

5(13.2%)

2(20.0%)

1(14.3%)

0.109

 Reperfusion pulmonary edema

3(4.4%)

0

1(10.0%)

4(57.1%)

0.497

 Pulmonary infection

27(39.7%)

18(47.4%)

6(60.0%)

7(100%)

0.028

 Re-exploration

3(4.4%)

2(5.3%)

1(10.0%)

0

1.000

 Tracheotomy

2(2.9%)

0

3(30%)

4(57.1%)

0.085

 Pericardial effusion

4(5.9%)

3(7.9%)

1(10.0%)

1(14.3%)

0.740

 Stroke

1(1.5%)

0

0

0

1.000

 Debridement

2(2.9%)

0

0

0

0.572

  1. BMI Body mass index, CAD Coronary artery disease; Renal insufficiency, preoperative serum creatinine > 1.2 mg/dL; anemia, hemoglobin< 120 g/L in male and hemoglobin< 110 g/L in female, CPB Cardiopulmonary bypass, DHCA Deep hypothermia circulatory arrest, RRT Renal replacement therapy, ECMO Extracorporeal membrane oxygenation
  2. *Comparisons between patients without AKI and with AKI