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Table 2 Peri-operative data

From: Effect of ulinastatin on post-operative blood loss and allogeneic transfusion in patients receiving cardiac surgery with cardiopulmonary bypass: a prospective randomized controlled study with 10-year follow-up

 

Ulinastatin group

(n = 142)

Tranexamic acid group (n = 143)

Placebo group

(n = 141)

P

Surgical procedures

0.733

 On-pump coronary artery bypass grafting, n (%)

16 (11.27%)

13 (9.09%)

21 (14.89%)

 

 Mitral valvuloplasty/replacement, n (%)

66 (46.48%)

65 (45.45%)

60 (42.55%)

 

 Aortic valve replacement, n (%)

23 (16.20%)

21 (14.69%)

19 (13.48%)

 

 Mitral and aortic valve replacement, n (%)

17 (11.97%)

15 (10.49%)

15 (10.64%)

 

 Coronary bypass and valvular surgery, n (%)

10 (7.04%)

7 (4.90%)

7 (4.96%)

 

 Repair of atrial septal defect, n (%)

1 (0.70%)

4 (2.80%)

6 (4.26%)

 

 Repair of ventricular septal defect, n (%)

4 (2.82%)

6 (4.20%)

5 (3.55%)

 

 Other

5 (3.52%)

12 (8.39%)

8 (5.67%)

 

Operative data

 Total dose of heparin (IU/kg)

28,331.69 ± 6695.96

28,729.51 ± 6612.39

28,653.19 ± 6738.07

0.924

 Total dose of protamine (mg)

393.28 ± 111.35

408.17 ± 117.55

407.87 ± 111.6

0.415

 Heparin neutralization ratio

1.41 ± 0.34

1.45 ± 0.38

1.46 ± 0.39

0.510

 Aortic cross-clamp time (min)

75.23 ± 34.8

68.77 ± 34.56

72.32 ± 38.09

0.186

 CPB time (min)

102.87 ± 42.74

95.60 ± 42.07

98.69 ± 47.76

0.205

 Chest closure time (min)

66.71 ± 30.44

64.04 ± 24.8

67.04 ± 30.93

0.888

 Operation time (min)

216.8 ± 64.03

206.46 ± 62.25

205.28 ± 65.36

0.156

 Inotropic support, n (%)

141 (99.3%)

140 (97.9%)

138 (97.87%)

0.559

 Operative mortality

0

0

0

–

Postoperative time course

 Mechanical ventilation (hrs)

15.0 ± 7.66

14.92 ± 10.58

16.95 ± 20.85

0.609

 ICU stay (hrs)

38.94 ± 26.91

38.06 ± 29.94

42.23 ± 35.3

0.741

 Chest tube removal (hrs)

50.39 ± 25.68

49.92 ± 18.29

48.01 ± 23.54

0.649

 Hospital length of stay (days)

8.24 ± 3.19

8.05 ± 2.46

8.51 ± 2.79

0.338