| Ulinastatin group (n = 142) | Tranexamic acid group (n = 143) | Placebo group (n = 141) | P |
---|---|---|---|---|
Surgical procedures | 0.733 | |||
 On-pump coronary artery bypass grafting, n (%) | 16 (11.27%) | 13 (9.09%) | 21 (14.89%) |  |
 Mitral valvuloplasty/replacement, n (%) | 66 (46.48%) | 65 (45.45%) | 60 (42.55%) |  |
 Aortic valve replacement, n (%) | 23 (16.20%) | 21 (14.69%) | 19 (13.48%) |  |
 Mitral and aortic valve replacement, n (%) | 17 (11.97%) | 15 (10.49%) | 15 (10.64%) |  |
 Coronary bypass and valvular surgery, n (%) | 10 (7.04%) | 7 (4.90%) | 7 (4.96%) |  |
 Repair of atrial septal defect, n (%) | 1 (0.70%) | 4 (2.80%) | 6 (4.26%) |  |
 Repair of ventricular septal defect, n (%) | 4 (2.82%) | 6 (4.20%) | 5 (3.55%) |  |
 Other | 5 (3.52%) | 12 (8.39%) | 8 (5.67%) |  |
Operative data | ||||
 Total dose of heparin (IU/kg) | 28,331.69 ± 6695.96 | 28,729.51 ± 6612.39 | 28,653.19 ± 6738.07 | 0.924 |
 Total dose of protamine (mg) | 393.28 ± 111.35 | 408.17 ± 117.55 | 407.87 ± 111.6 | 0.415 |
 Heparin neutralization ratio | 1.41 ± 0.34 | 1.45 ± 0.38 | 1.46 ± 0.39 | 0.510 |
 Aortic cross-clamp time (min) | 75.23 ± 34.8 | 68.77 ± 34.56 | 72.32 ± 38.09 | 0.186 |
 CPB time (min) | 102.87 ± 42.74 | 95.60 ± 42.07 | 98.69 ± 47.76 | 0.205 |
 Chest closure time (min) | 66.71 ± 30.44 | 64.04 ± 24.8 | 67.04 ± 30.93 | 0.888 |
 Operation time (min) | 216.8 ± 64.03 | 206.46 ± 62.25 | 205.28 ± 65.36 | 0.156 |
 Inotropic support, n (%) | 141 (99.3%) | 140 (97.9%) | 138 (97.87%) | 0.559 |
 Operative mortality | 0 | 0 | 0 | – |
Postoperative time course | ||||
 Mechanical ventilation (hrs) | 15.0 ± 7.66 | 14.92 ± 10.58 | 16.95 ± 20.85 | 0.609 |
 ICU stay (hrs) | 38.94 ± 26.91 | 38.06 ± 29.94 | 42.23 ± 35.3 | 0.741 |
 Chest tube removal (hrs) | 50.39 ± 25.68 | 49.92 ± 18.29 | 48.01 ± 23.54 | 0.649 |
 Hospital length of stay (days) | 8.24 ± 3.19 | 8.05 ± 2.46 | 8.51 ± 2.79 | 0.338 |