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Table 1 Quality of Evidence of Included Studies

From: Structural durability of early-generation Transcatheter aortic valve replacement valves compared with surgical aortic valve replacement valves in heart valve surgery: a systematic review and meta-analysis

Certainty assessment№ of patientsEffectCertaintyImportance
№ of studiesStudy designRisk of biasInconsistencyIndirectnessImprecisionOther considerationsTAVR valveSAVR valveRelative (95% CI)Absolute (95% CI)
Transcatheter aortic-valve replacement with a self-expanding prosthesis15
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone390/747 (52.2%)357/747 (47.8%)not estimable  HIGHCRITICAL
3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement16
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone391/750 (52.1%)359/750 (47.9%)not estimable  HIGH CRITICAL
Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial17
1randomised trialsserious a,bnot seriousnot seriousnot seriousnone2482/2795 (88.8%)313/2795 (11.2%)not estimable  MODERATE CRITICAL
5-Year Outcomes of Self-Expanding Transcatheter Versus Surgical Aortic Valve Replacement in High-Risk Patients18
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone390/744 (52.4%)354/744 (47.6%)not estimable  HIGH CRITICAL
Comparison of Transcatheter and Surgical Aortic Valve Replacement in Severe Aortic Stenosis: A Longitudinal Study of Echo Parameters in Cohort A of the PARTNER Trial19
1randomised trialsserious bnot seriousnot seriousnot seriousnone348/699 (49.8%)351/699 (50.2%)not estimable  MODERATECRITICAL
Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients20
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone1101/2032 (54.2%)1021/2032 (50.2%)not estimable  HIGHCRITICAL
Self-Expanding Transcatheter Aortic Valve Replacement Versus Surgical Valve Replacement in Patients at High Risk for Surgery A Study of Echocardiographic Change and Risk Prediction21
1randomised trialsserious bnot seriousnot seriousnot seriousnone389/795 (48.9%)353/795 (44.4%)not estimable  MODERATECRITICAL
5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised trial22
1randomised trialsserious anot seriousnot seriousnot seriousnone348/699 (49.8%)351/699 (50.2%)not estimable  MODERATECRITICAL
Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients [9]
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone864/1660 (52.0%)796/1660 (48.0%)not estimable  HIGHCRITICAL
Durability of Transcatheter and Surgical Bioprosthetic Aortic Valves in Patients at Lower Surgical Risk [10]
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone139/274 (50.7%)135/274 (49.3%)not estimable  HIGHCRITICAL
Five-Year Clinical and Echocardiographic Outcomes From the NOTION Randomized Clinical Trial in Patients at Lower Surgical Risk [11]
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone145/280 (51.8%)135/280 (48.2%)not estimable HIGHCRITICAL
Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Valve Stenosis: 1-Year Results From the All-Comers NOTION Randomized Clinical Trial [12]
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone145/280 (51.8%)135/280 (48.2%)not estimable  HIGHCRITICAL
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients [8]
1randomised trialsnot seriousnot seriousnot seriousnot seriousnone725/1403 (51.7%)678/1403 (48.3%)not estimable  HIGHCRITICAL
  1. CI Confidence interval
  2. Explanations
  3. a. Patients and their treating physicians were not masked to treatment allocation
  4. b. Attrition bias due to amount, nature or handling of incomplete outcome data