Table 1 Quality of Evidence of Included Studies
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | TAVR valve | SAVR valve | Relative (95% CI) | Absolute (95% CI) | ||
Transcatheter aortic-valve replacement with a self-expanding prosthesis15 | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 390/747 (52.2%) | 357/747 (47.8%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement16 | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 391/750 (52.1%) | 359/750 (47.9%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial17 | ||||||||||||
1 | randomised trials | serious a,b | not serious | not serious | not serious | none | 2482/2795 (88.8%) | 313/2795 (11.2%) | not estimable | ⨁⨁⨁◯ MODERATE | CRITICAL | |
5-Year Outcomes of Self-Expanding Transcatheter Versus Surgical Aortic Valve Replacement in High-Risk Patients18 | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 390/744 (52.4%) | 354/744 (47.6%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Comparison of Transcatheter and Surgical Aortic Valve Replacement in Severe Aortic Stenosis: A Longitudinal Study of Echo Parameters in Cohort A of the PARTNER Trial19 | ||||||||||||
1 | randomised trials | serious b | not serious | not serious | not serious | none | 348/699 (49.8%) | 351/699 (50.2%) | not estimable | ⨁⨁⨁◯ MODERATE | CRITICAL | |
Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients20 | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 1101/2032 (54.2%) | 1021/2032 (50.2%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Self-Expanding Transcatheter Aortic Valve Replacement Versus Surgical Valve Replacement in Patients at High Risk for Surgery A Study of Echocardiographic Change and Risk Prediction21 | ||||||||||||
1 | randomised trials | serious b | not serious | not serious | not serious | none | 389/795 (48.9%) | 353/795 (44.4%) | not estimable | ⨁⨁⨁◯ MODERATE | CRITICAL | |
5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised trial22 | ||||||||||||
1 | randomised trials | serious a | not serious | not serious | not serious | none | 348/699 (49.8%) | 351/699 (50.2%) | not estimable | ⨁⨁⨁◯ MODERATE | CRITICAL | |
Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients [9] | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 864/1660 (52.0%) | 796/1660 (48.0%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Durability of Transcatheter and Surgical Bioprosthetic Aortic Valves in Patients at Lower Surgical Risk [10] | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 139/274 (50.7%) | 135/274 (49.3%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Five-Year Clinical and Echocardiographic Outcomes From the NOTION Randomized Clinical Trial in Patients at Lower Surgical Risk [11] | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 145/280 (51.8%) | 135/280 (48.2%) | not estimable | ⨁⨁⨁⨁HIGH | CRITICAL | |
Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Valve Stenosis: 1-Year Results From the All-Comers NOTION Randomized Clinical Trial [12] | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 145/280 (51.8%) | 135/280 (48.2%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients [8] | ||||||||||||
1 | randomised trials | not serious | not serious | not serious | not serious | none | 725/1403 (51.7%) | 678/1403 (48.3%) | not estimable | ⨁⨁⨁⨁ HIGH | CRITICAL | |