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Table 1 The characteristics of the included studies

From: Both the presence of a micropapillary component and the micropapillary predominant subtype predict poor prognosis after lung adenocarcinoma resection: a meta-analysis

First Author (year) Study Region Starting and Ending Year MP Pattern Definition Total Number of Patients Number of MP Patients Age TNM Staging Distribution Surgical Approach Median Follow-up Time Outcome
I II III IV Lobecto-my Limited Resection Pneumon-ectomy Bilob-
ectomy
  
Presence of micropapillary component
Liu (2014) [17] China 2007.5–2012.2 MP component 248 79 60 (24–81) 110 30 81 27       OS
Tsubokawa(2016) [18] Japan 2006.4–2010.12 MP component 347 49 unclear 325 11 11   192 155    40.6 DFS
Moon (2016) [19] Korea 2010.1–2014.12 MP component 168 37 unclear 133 35    163    3 29.1 (0.4–62.2) DFS
Yao
(2016) [13]
China 2012.9–2014.2 MP component 20 5 62 (43–80) 7 8 5   17 3    30 (24–41) DFS
Yi (2018) [14] Korea 2009–2012 MP component 368 141 62.6 (30–91) 368     250 114 1   43 (0–73.9) DFS
Micropapillary predominant subtype
Westaway (2013) [20] Australia 2000–2010 MP predominant 152 8 68 (31–100) 79 42 31   133 8 11    OS
Sun (2014) [21] China 2002.1–2011.12 MP predominant 136 22 57.6 (34–79) 136     119    17 74 (21–145) DFS, OS
Warth (2015) [22] Germany 2002–2010 MP predominant 674 53 62.6 264 145 243 22 549 22 87 16 38.2 DFS
Watanabe (2015) [8] Japan 1998–2007 MP predominant 2316 139 unclear I + II 1912 III + IV 404       OS
Zhang(2016) [9] China 2007.1–2010.6 MP predominant 505 49 57 (24–83) 221 81 203   443 19 11 32 43 (22.9–57.5) DFS, OS
  1. MP pattern definition: Semiquantitative record various patterns that may be present in 5% increments, the presence of MP component is defined as the proportion of MP pattern > 5%, and the MP predominant subtype defined as the MP pattern present in the largest proportion [3, 4]