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Table 4 Cox proportional hazard model for cumulative all-cause mortality after thoracic aorta replacement surgery

From: Association between institutional case volume and mortality following thoracic aorta replacement: a nationwide Korean cohort study

 

Univariable model

Multivariable model

HR (95% CI)

P

HR (95% CI)

P

Case volume strata

 High volume (> 60 cases/year)

Reference

 

Reference

 

 Low & medium volume (≤60 cases/year)a

1.53 (1.37–1.70)

< 0.001

1.55 (1.38–1.74)

< 0.001

Age

 ≤ 49

Reference

 

Reference

 

 50–59

1.23 (0.98–1.53)

0.070

1.27 (1.02–1.58)

0.036

 60–69

1.80 (1.49–2.18)

< 0.001

1.87 (1.54–2.28)

< 0.001

 70–79

3.08 (2.58–3.67)

< 0.001

3.24 (2.67–3.93)

< 0.001

 ≥ 80

4.22 (3.39–5.25)

< 0.001

4.70 (3.73–5.93)

< 0.001

Female

0.97 (0.88–1.08)

0.621

0.73 (0.65–0.82)

< 0.001

Extracardiac arteriopathy

1.43 (1.24–1.65)

< 0.001

1.15 (1.00–1.33)

0.058

Renal impairment

3.02 (2.23–4.09)

< 0.001

1.89 (1.39–2.58)

< 0.001

Chronic lung disease

1.34 (1.20–1.49)

< 0.001

1.02 (0.91–1.14)

0.701

Hypertension

1.29 (1.16–1.44)

< 0.001

0.94 (0.83–1.06)

0.320

Hyperlipidemia

1.25 (1.11–1.41)

< 0.001

1.01 (0.89–1.15)

0.896

Diabetes

1.49 (1.25–1.76)

< 0.001

1.07 (0.90–1.28)

0.448

Angina pectoris

1.23 (1.09–1.39)

0.001

0.99 (0.87–1.13)

0.852

Recent MI

1.43 (1.02–2.01)

0.040

1.22 (0.86–1.73)

0.269

History of PCI

1.94 (1.28–2.93)

0.002

1.05 (0.68–1.61)

0.829

Congestive heart failure

1.44 (1.22–1.70)

< 0.001

1.17 (0.98–1.40)

0.081

Emergent surgery

1.35 (1.07–1.71)

0.012

1.37 (1.07–1.75)

0.012

Atrial fibrillation

1.45 (1.17–1.81)

0.001

1.17 (0.93–1.46)

0.178

Perioperative RBC Transfusion

 0–1 units

Reference

 

Reference

 

 2–3 units

2.32 (1.56–3.44)

< 0.001

1.80 (1.21–2.67)

0.004

 4–5 units

3.76 (2.52–5.59)

< 0.001

2.74 (1.83–4.08)

< 0.001

 6- units

9.02 (6.09–13.37)

< 0.001

5.95 (4.00–8.85)

< 0.001

Surgery site

 Ascending aorta

Reference

 

Reference

 

 Aortic arch

1.72 (1.41–2.09)

< 0.001

1.46 (1.20–1.79)

< 0.001

 Descending thoracic aorta

1.10 (0.95–1.27)

0.193

1.25 (1.06–1.46)

0.006

 Combined

1.02 (0.90–1.16)

0.760

1.08 (0.94–1.23)

0.287

  1. CI Confidence interval, HR Hazard ratio, MI Myocardial infarction, PCI Percutaneous coronary intervention, RBC Red blood cell
  2. aLow- and medium-volume groups were merged into one group prior to the multivariable analysis to meet the proportional hazard assumption
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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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