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Table 4 Logistic regression analysis for in-hospital mortality

From: Characteristics and outcomes of Stanford type A aortic dissection patients with severe post-operation hyperbilirubinemia: a retrospective cohort study

Characteristic Univariate logistic regression Multivariate logistic regression (model 1) Multivariate logistic regression (model 2)
OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Age (year) 1.035 (1.009–1.062) 0.008 1.005 (1.004–1.099) 0.033 1.046 (1.002–1.093) 0.040
Male (yes/no) 2.483 (1.106–5.575) 0.027     
Preoperative
 SCr 1.009 (1.002–1.016) 0.008     
 APACHE II score 1.178 (1.082–1.282) < 0.001     
Intraoperative
 CPB time 1.007 (1.003–1.011) 0.002     
 ACC time 1.012 (1.002–1.021) 0.014     
 Deep hypothermic circulatory arrest time 0.997 (0.979–1.016) 0.787     
Postoperative
 MAP 0.948 (0.926–0.971) < 0.001 0.955 (0.922–0.990) 0.012 0.963 (0.930–0.977) 0.031
 Re-operation (yes/no) 3.611 (1.324–9.852) 0.012     
 The total amount of blood transfusion 1.046 (1.032–1.060) < 0.001 1.018 (1.003–1.033) 0.019 1.020 (1.005–1.034) 0.007
 Mechanical ventilation time 1.533 (1.341–1.798) < 0.001     
 AKI (yes/no) 28.350 (3.842–209.203) 0.001     
 Stage of AKI   < 0.001   < 0.001   < 0.001
  Stage 1 5.859 (0.735–46.720) 0.095 2.424 (0.267–21.990) 0.431 2.218 (0.253–19.426) 0.472
  Stage 2 10.138 (1.162–88.457) 0.036 4.560 (0.478–43.545) 0.187 3.698 (0.385–35.548) 0.257
  Stage 3 165.053 (21.354–1275.729) < 0.001 46.134 (5.436–391.525) < 0.001 46.318 (5.666–378.663) < 0.001
 Use of CRRT (yes/no) 23.756 (10.359–54.481) 0.001     
 Use of PE/BA (yes/no) 11.527 (2.432–54.631) 0.002     
 Use of ECMO (yes/no) 14.842 (1.757–125.357) 0.013 20.795 (1.620–266.917) 0.02 10.130 (0.900–113.958) 0.061
 Peak TB concentration 1.009 (1.005–1.012) < 0.001 1.017 (1.002–1.032) 0.023   
 Peak TB ≥121 μmol/l, (yes/no) 3.899 (2.220–6.847) < 0.001    2.681 (1.119–6.425) 0.027
 Time to peak TB concentration 1.441 (1.277–1.626) < 0.001     
ICU stay time 1.268 (1.172–1.371) < 0.001     
  1. Model 1 was established by analysis of peak TB concentration; Model 2 was established by subgroup analysis of peak bilirubin concentration greater or less than 121.2 μmol/l
  2. ACC Aortic cross clamp, AKI Acute kidney injury, APACHEII Acute physiology and chronic health evaluation II, BA Bilirubin adsorption, CPB Cardiopulmonary bypass, CRRT Continuous renal replacement therapy, ECMO Extracorporeal membrane oxygenation, ICU Intensive care unit, MAP Mean arterial pressure, PE Plasma exchange, SCr Serum creatinine, TB Total bilirubin