Table 3 Characteristics of the patients with acute aortic syndrome
No AKI | AKI Stage | P1 Value* | P2 Value# | |||
|---|---|---|---|---|---|---|
1 | 2 | 3 | ||||
Patient population (n) | 56 | 71 | 36 | 24 | ||
Demographic data | ||||||
Age (y) | 48.0 (16.5) | 48.0 (15.0) | 48.0 (13.5) | 41.0 (8.3) | 0.2 | 0.07 |
Sex, male (n) | 31 (55.4%) | 52 (73.2%) | 24 (66.7%) | 18 (75.0%) | 0.03 | 0.1 |
Height (cm) | 170.0 (12.8) | 171.0 (7.0) | 172.0 (10.5) | 170.0 (13.0) | 0.4 | 0.5 |
Weight (kg) | 71.9 ± 10.2 | 78.0 ± 12.6 | 77.1 ± 14.4 | 77.8 ± 13.4 | 0.003 | 0.07 |
BMI (kg/m2) | 25.5 ± 2.8 | 25.7 ± 5.6 | 26.4 ± 3.9 | 28.2 ± 3.7 | 0.3 | 0.2 |
Medical history | ||||||
Diabetes (n) | 2 (3.6%) | 1 (1.4%) | 2 (5.6%) | 1 (4.2%) | 0.9 | 0.7 |
Hypertension (n) | 38 (67.9%) | 46 (64.8%) | 30 (83.3%) | 23 (95.8%) | 0.3 | 0.009 |
Chronic obstructive pulmonary disease (n) | 1 (1.8%) | 1 (1.4%) | 0 (0.0%) | 0 (0.0%) | 0.5 | 0.8 |
Peripheral vascular disease (n) | 4 (7.1%) | 5 (7.0%) | 4 (11.1%) | 1 (4.2%) | 0.9 | 0.8 |
Smoking (n) | 17 (30.4%) | 21 (29.6%) | 13 (36.1%) | 9 (37.5%) | 0.7 | 0.8 |
Preoperative laboratory tests | ||||||
Platelet (109/L) | 195.5 (106.0) | 191.0 (82.0) | 191.0 (83.3) | 177.0 (65.5) | 0.1 | 0.2 |
Lymphocyte (109/L) | 1.39 (0.75) | 1.24 (0.81) | 1.13 (0.59) | 1.41 (0.99) | 0.01 | 0.03 |
Monocyte (109/L) | 0.70 (0.56) | 0.67 (0.60) | 0.89 (0.63) | 0.92 (0.82) | 0.03 | 0.03 |
Neutrophil (109/L) | 7.39 ± 3.60 | 7.76 ± 3.41 | 8.97 ± 3.33 | 10.52 ± 3.76 | 0.04 | 0.001 |
Hyperlipidemia (n) | 14 (25.0%) | 16 (22.5%) | 3 (8.3%) | 9 (37.5%) | 0.6 | 0.02 |
Retinol binding protein (mg/L) | 27.6 (24.1) | 27.9 (17.1) | 21.2 (16.4) | 37.3 (25.2) | 0.7 | 0.02 |
Preoperative renal function | ||||||
Dissection involving renal artery (n) | 4 (7.1%) | 6 (8.5%) | 4 (11.1%) | 5 (20.8%) | 0.4 | 0.3 |
Preoperative SCr (μmol/L) | 65.5 (31.0) | 75.0 (24.4) | 68.5 (36.2) | 81.1 (47.9) | 0.2 | 0.2 |
> 106 (n) | 6 (10.7%) | 10 (14.1%) | 4 (11.1%) | 7 (29.2%) | 0.3 | 0.2 |
Surgical details | ||||||
Involving the aortic arch (n) | 50 (89.3%) | 66 (93.0%) | 35 (97.2%) | 24 (100.0%) | 0.1 | 0.2 |
Involving the descending aorta (n) | 43 (76.8%) | 59 (83.1%) | 33 (91.7%) | 23 (95.8%) | 0.06 | 0.1 |
CPB duration (min) | 188.0 (38.8) | 201.0 (44.0) | 222.0 (51.8) | 235.0 (60.0) | < 0.001 | < 0.001 |
DHCA or MHCA (n) | 48 (85.7%) | 65 (91.5%) | 34 (94.4%) | 23 (95.8%) | 0.1 | 0.4 |
Aortic cross-clamp time (min) | 94.5 (21.8) | 99.0 (31.0) | 96.0 (32.5) | 110.0 (29.0) | 0.02 | 0.02 |
Operation time (h) | 7.0 (1.5) | 8.0 (1.5) | 8.5 (1.9) | 9.0 (2.5) | < 0.001 | < 0.001 |
Combined surgery | ||||||
CABG (n) | 1 (1.8%) | 2 (2.8%) | 0 (0.0%) | 3 (12.5%) | 0.5 | 0.04 |
Valvular surgery (n) | 8 (14.3%) | 7 (9.9%) | 1 (2.8%) | 0 (0.0%) | 0.07 | 0.1 |
Outcomes | ||||||
Renal replacement therapy (n) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 11 (45.8%) | 0.03 | < 0.001 |
Length of ICU stay (day) | 5.0 (3.8) | 5.0 (2.0) | 5.0 (4.0) | 12.0 (11.5) | 0.02 | < 0.001 |
> 7 d (n) | 17 (30.4%) | 16 (22.5%) | 13 (36.1%) | 22 (91.7%) | 0.3 | < 0.001 |
Intubation time (h) | 19.0 (20.0) | 24.0 (32.0) | 40.5 (75.8) | 147.5 (81.0) | < 0.001 | < 0.001 |
> 5 d (n) | 4 (7.1%) | 4 (5.6%) | 5 (13.9%) | 17 (70.8%) | 0.03 | < 0.001 |
Redo surgery (n) | 2 (3.6%) | 2 (2.8%) | 5 (13.9%) | 6 (25.0%) | 0.1 | 0.002 |
In-hospital mortality (n) | 1 (1.8%) | 1 (1.4%) | 0 (0.0%) | 7 (29.2%) | 0.2 | < 0.001 |