Table 2 The registered trials of non-intubated or tubeless thoracoscopic lung surgery
Registration identifier | Year | Disease | Anaesthesia method | Estimated enrollment | Major outcomes | Status | Country |
|---|---|---|---|---|---|---|---|
NCT00566839 | 2007 | Emphysema | TEA | 60 | Mortality, FEV1, dyspnea index | Completed | Italy |
NCT01469728 | 2011 | NR | TEA | 40 | Grade of medical care | Completed | Italy |
NCT01677442 | 2011 | NR | TEA at the T5/T6 | 500 | Recovery time | Unknown | China |
NCT01533233 | 2012 | Lung cancer | NR | 100 | Complication and morbidity | Unknown | China |
NCT02109510 | 2014 | Pneumothorax | Sedation anesthesia + intercostal nerve block | 40 | Postoperative discomforts | Completed | Korea |
NCT02123173 | 2014 | Lung neoplasms | NR (one lung ventilation) | 71 | Cardiac output | Completed | China |
NCT02393664 | 2015 | Lung neoplasms | General anesthesia + intercostal/vagal blocks | 300 | Quality of recovery | Unknown | China |
NCT02817048 | 2016 | Solitary lung nodule | NR (Tubeless) | 100 | Postoperative hospital stay | Not yet recruiting | China |
NCT03275428 | 2017 | Lung nodule | Intravenous sedation | 40 | Arterial oxygen pressure | Unknown | China |
NCT03083080 | 2017 | NR | Intercostal nerve plane block | 30 | Pain, time to lose skin sensation | Unknown | China |
NCT03086213 | 2017 | NR | Paravertebral/intercostal nerve block | 48 | The change of stress response markers | Unknown | China |
NCT03016858 | 2017 | Bulla | Intravenous anesthesia | 320 | Complications | Recruiting | China |
NCT03137576 | 2017 | Lung neoplasms | Erector spinae plane block/paravertebral block and sedation | 172 | Percentage of sedation escalation | Recruiting | Italy |
ChiCTR-INR-17012747 | 2017 | Thoracic diseases | General anesthesia | 30 | Length of hospital stay | Recruiting | China |
ChiCTR-IPR-17013325 | 2017 | Lung nodule | Intravenous anesthesia | 120 | CD3+, CD8+, CD4+, CD19+, NK cell concentration | Not yet recruiting | China |
NCT03711461 | 2018 | NR | NR | 32 | Impedance changes (swallowing) | Recruiting | China |
NCT03432637 | 2018 | Lung cancer | Spontaneous ventilating anesthesia | 450 | Hypoxemia or hypercapnia | Recruiting | China |
NCT03471884 | 2018 | Lung cancer | General anesthesia | 82 | Lung function | Recruiting | China |
NCT03469323 | 2018 | NR | NR (one-lung spontaneous breathing) | 30 | Quality of lung collapse | Recruiting | China |
ChiCTR1800018198 | 2018 | NR | Paravertebral nerve block + laryngeal mask | 110 | Glottal injury, sore throat | Recruiting | China |
NCT03653494 | 2018 | NR | General anesthesia + paravertebral block + surface spray anesthesia + vagus block with or without phrenic block | 80 | Anesthetic drugs needed | Enrolling by invitation | China |
ChiCTR1800018204 | 2018 | NR | Serratus anterior plane/erector spinae plane/paravertebral block | 90 | Nerve block time | Not yet recruiting | China |
ChiCTR1800017854 | 2018 | T1a (<2 cm) peripheral lung adenocarcinoma | NR (Tubeless) | 200 | Complications | Not yet recruiting | China |
NCT03874403 | 2019 | NR | Intercostal nerve block | 60 | The density spectral array | Recruiting | China |
NCT04057586 | 2019 | NR | NR (one lung ventilation) | 240 | Intraoperative cerebral oxygenation | Recruiting | China |
ChiCTR1900027350 | 2019 | Lung cancer | Intercostal/paravertebral nerve block + general anesthesia using laryngeal mask | 80 | Hemodynamics, general anesthetic dose, recovery time | Recruiting | China |
ChiCTR1900022020 | 2019 | Thoracic disease | General anesthesia | 120 | Glottal injury incidence, lung collapse score | Recruiting | China |
NCT03958162 | 2019 | Interstitial lung disease | NR (tubeless) | 60 | Diagnostic yield after biopsy | Not yet recruiting | China |
NCT03902470 | 2019 | Lung cancer | TEA | 30 | Recovery time | Not yet recruiting | Egypt |