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Table 1 Demographics and Perioperative Characteristics of the HTx Recipients Stratified by eGFR

From: Incidence, risk factors and clinical outcomes of acute kidney injury after heart transplantation: a retrospective single center study

 

Overall

(n = 95)

eGFR (ml/min/1.73 m2)

P value

< 30 (n = 25)

30–59 (n = 61)

≥60 (n = 9)

Demographic data

 Age, years

54.31 ± 11.92

58.88 ± 9.75

55.15 ± 9.20

35.89 ± 17.20

0.0007*

 Sex, men, n (%)

81(85.26)

19(76.00)

54(88.52)

8(88.89)

0.318

 BMI (kg/m2)

24.54 ± 3.83

23.89 ± 3.15

24.70 ± 4.08

25.25 ± 3.92

0.575

 History of alcohol

29(30.53)

10(40.00)

17(27.87)

2(22.22)

0.464

 History of smoking

63(66.32)

16(64.00)

41(67.21)

6(66.67)

0.960

 Hypertension

39(41.05)

15(60.00)

21(34.43)

3(33.33)

0.083

 Diabetes mellitus

34(35.79)

12(48.00)

19(31.15)

3(33.33)

0.334

 Chronic kidney disease

20(21.05)

12(48.00)

6(9.84)

2(22.22)

0.0005*

Pretransplant characteristics

 DCM

38(40.00)

7(28.00)

26(42.62)

5(55.56)

0.279

 CAD

27(28.42)

9(36.00)

16(26.23)

2(22.22)

0.604

 Valve disease

15(15.79)

3(12.00)

10(16.39)

2(22.22)

0.756

 Pre-PCI

11(11.58)

4(16)

7(11.48)

0(0)

0.441

 ICD implantation

3(3.16)

2(8.00)

1(1.64)

0(0)

0.267

 LVAD implantation

1(1.05)

0(0)

0(0)

1(11.11)

0.008*

 Cardiac tumor

1(1.05)

0(0)

1(1.64)

0(0)

0.755

 EF pre-HTx (%)

28(23,31)

30(24,33)

26(23,30)

25(20,30)

0.257

 Creatinine (mg/dL)

1.14(0.95,1.27)

1.60(1.33,1.91)

1.10(0.95,1.22)

0.76(0.70,0.87)

<.0001*

Intraoperative characteristics

 CPB duration (min)

225(183,262)

225(180,270)

220(193,255)

210(180,225)

0.822

 Blood transfusion (ml)

1440(1100,2100)

1400(1100,2000)

1440(1100,2200)

1640(1000,2050)

0.849

 Infusion (ml)

1810(1320,2440)

2000(1505,2580)

1800(1320,2350)

1700(1190,1925)

0.483

 Blood loss (ml)

1000(1000,2200)

1500(1000,2500)

1000(1000,2000)

1500(1000,2000)

0.804

 Urine volume (ml)

1800(1200,2500)

1300(770,1650)

2000(1300,2500)

2150(2000,2900)

0.001*

 IABP/ECMO

6(6.32)

4(16.00)

2(3.28)

0(0)

0.065

Postoperative characteristics

 AKI stage

  NO-AKI

62(65.26)

16(64.00)

40(65.57)

6(66.67)

0.428

  Stage 1

9(9.47)

0(0)

8(13.11)

1(11.11)

 

  Stage 2

8(8.42)

2(8.00)

4(6.56)

2(22.22)

  Stage 3

16(16.84)

7(28.00)

9(14.75)

0(0)

Urine volume

 1st Day after operation

2200(1980,2805)

2100(1965,2485)

2200(1980,2735)

2525(2115,3320)

0.194

 2nd Day after operation

2125(1765,2505)

1935(1400,2498)

2135(1845,2500)

2425(2005,2970)

0.081

 3rd Day after operation

2110(1860,2050)

2050(1400,2498)

2145(1930,2450)

2305(2050,2440)

0.300

 Mechanical ventilation (min)

1080(840,2220)

1920(960,3720)

1040(783,2100)

960(720,1410)

0.134

 RRT

16(16.84)

7(28.00)

9(14.75)

0(0)

0.123

 Time from operation to discharge (days)

26(22,33)

29(23,37)

26(22,32)

24(20,26)

0.370

 Death

15(15.79)

4(16.00)

10(16.39)

1(11.11)

0.921

 Mortality in hospital

11(11.58)

4(16.00)

6(9.84)

1(11.11)

0.719

 Death within 1 year

3(3.16)

0(0)

3(4.92)

0(0)

0.422

 Follow-up days

608(303,1180)

555(341,951)

692(276,1180)

1451(497,2132)

0.199

  1. * P < 0.05; eGFR was calculated using the Chronic Kidney Disease Epidemiology collaboration equation. HTx Heart transplantation, eGFR Estimated glomerular filtration rate, BMI Body mass index, DCM Dilated cardiomyopathy, CAD Coronary arterial disease, Pre-PCI Previous percutaneous coronary intervention, ICD Implantable cardioverter defibrillator, LVAD Left ventricular assist device, CPB Cardiopulmonary bypass, RRT Renal replacement therapy. Numbers in brackets are interquartile ranges (IQRs). ANOVA was applied to the BMI variable because of its normal distribution. The Kruskal-Wallis test was used to compare other variables