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Table 3 Anticoagulation and postoperative outcome

From: Bleeding complications after cardiac surgery, before anticoagulation start and then with argatroban or heparin in the early postoperative setting

 Study populationheparin (H)argatroban (A)H vs. A
p-value
switched (S)H vs. S
p-value
Number2151434329
 % (n) o.
mean (range)
% (n) o.
mean (range)
% (n) o.
mean (range)
% (n) o.
mean (range)
Duration ICU (days)6.3 (2–54)4 (2–54)9.47 (2–39)< 0.00112.83 (2–46)< 0.001
Need for transfusion83.3% (179)74.8% (107)100% (43)< 0.001100% (29)0.001
Death8.8% (19)2.8% (4)20.9% (9)< 0.00120.7% (6)0.002
Due to bleeding0% (0)0% (0)0% (0)n.s.0% (0)n.s.
Other reasons100%100%100% (43)n.s.100% (29)n.s.
MELD max.14.5 (6–40)12.1 (6–34)19.53 (7–40)< 0.00118.86 (8–40)< 0.001
Bilirubin max.14.5 (6–40)1.5 (0.3–11.1)3.0 (0.3–15.3)0.0032.9 (0.6–14.9)0.041
Hepatic impairment4.2% (9)1.4% (2)9.3% (4)0.02610.3% (3)0.034
HIT PCR pos.3.7% (8)2.1% (3)7.0% (3)n.s.6.9% (2)n.s.
Need for reoperation18.6% (40)11.2% (16)32.6% (14)0.00234.5% (10)0.003
Due to bleeding72.5% (29)60% (9)92.9% (13)< 0.00170% (7)0.007
CVVHD20% (43)4.9% (7)44.2% (19)< 0.00158.7% (17)< 0.001
  1. CVVHD continuous veno-venous hemodialysis
  2. Values reaching significance are merked bold