Table 4 Monitored parameters of anticoagulation
Number | Study population n = 215 | heparin (H) n = 143 | argatroban (A) n = 43 | H vs. A p-value | Switched(S) n = 29 | H vs. S p-value |
|---|---|---|---|---|---|---|
mean (range) | mean (range) | mean (range) | mean (range) | |||
PTT pre-operative [s] | 30.1 (20–123) | 29.2 (20–108) | 33.2 (22–123) | n.s. (0.146) | 29.6 (23–47) | n.s. (0.847) |
PTT day 1 [s] | 40.8 (23- > 140) | 38.2 (23- > 140) | 47.2 (29- > 140) | 0.005 | 44,1 (24- > 140) | n.s. (0.229) |
PTT max. within 24 h after initiation of Anticoagulation [s] | 50.9 (23- > 140) | 44.4 (23- > 140) | 62.1 (37- > 140) | < 0.001 | 66.2 (33- > 140) | < 0.001 |
After first heparin infusion [s] | 45.9 (23- > 140) | 44.4 (23- > 140) | – | – | 53.6 (25- > 140) | n.s. (0.073) |
After first argatroban infusion [s] | 61.2 (33- > 140) | – | 62.1 (37- > 140) | – | 59.8 (33- > 140) | B vs. C n.s. (0.663) |
PTT max. Day 1–3 [s] | 57.1 (28–135) | 51.8 (28–135) | 68.0 (38–129) | < 0.001 | 66.5 (30–119) | 0.004 |
Quick preoperative [%] | 868 (17–101) | 89.3 (17–101) | 81.4 (27–101) | 0.032 | 82.3 (33–100) | 0.047 |
Quick day 1 [%] | 70.9 (16–101) | 75.5 (28–101) | 59.8 (16–98) | < 0.001 | 64.4 (22–99) | 0.001 |