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Table 4 Monitored parameters of anticoagulation

From: Bleeding complications after cardiac surgery, before anticoagulation start and then with argatroban or heparin in the early postoperative setting

NumberStudy population
n = 215
heparin (H)
n = 143
argatroban (A)
n = 43
H vs. A p-valueSwitched(S)
n = 29
H vs. S p-value
mean (range)mean (range)mean (range)mean (range)
PTT pre-operative [s]30.1 (20–123)29.2 (20–108)33.2 (22–123)n.s. (0.146)29.6 (23–47)n.s. (0.847)
PTT day 1 [s]40.8 (23- > 140)38.2 (23- > 140)47.2 (29- > 140)0.00544,1 (24- > 140)n.s. (0.229)
PTT max. within 24 h after initiation of Anticoagulation [s]50.9 (23- > 140)44.4 (23- > 140)62.1 (37- > 140)< 0.00166.2 (33- > 140)< 0.001
After first heparin infusion [s]45.9 (23- > 140)44.4 (23- > 140)53.6 (25- > 140)n.s. (0.073)
After first argatroban infusion [s]61.2 (33- > 140)62.1 (37- > 140)59.8 (33- > 140)B vs. C n.s. (0.663)
PTT max. Day 1–3 [s]57.1 (28–135)51.8 (28–135)68.0 (38–129)< 0.00166.5 (30–119)0.004
Quick preoperative [%]868 (17–101)89.3 (17–101)81.4 (27–101)0.03282.3 (33–100)0.047
Quick day 1 [%]70.9 (16–101)75.5 (28–101)59.8 (16–98)< 0.00164.4 (22–99)0.001
  1. Values reaching significance are merked bold