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Table 1 Clinical characteristics of patients with AAAD

From: Preoperative uric acid predicts in-hospital death in patients with acute type a aortic dissection

VariableAll patientsSurvivorNon-survivorp value
 (n = 186)(n = 146)(n = 40)
Demographics
 Age (years)50 ± 1249 ± 1255 ± 130.016
 Male, n (%)149 (80%)118 (81%)31 (78%)0.641
Medical histories, n (%)
 Hypertension105 (56%)80 (55%)25 (63%)0.384
 Diabetes6 (3%)5 (3%)1 (3%)1
 CKD7 (4%)7 (5%)0 (0%)0.349
 Prior aortic stent implant9 (5%)8 (5%)1 (3%)0.687
 Prior cardiac surgery3 (2%)3 (2%)0 (0%)1
 Smoker72 (39%)61 (42%)11 (28%)0.1
Clinical presentation
 Onset to operation time (hours)26 (17–39)28 (19–42)20 (14–32)0.011
 Systolic blood pressure (mmHg)129 ± 30129 ± 29127 ± 320.7
 Diastolic blood pressure (mmHg)72 ± 1972 ± 1972 ± 220.949
 Heart rate (beats/min)80 (68–91)80 (69–91)79 (66–88)0.763
 Ascending aorta diameter (mm)42 (40–50)42 (39–50)44 (41–48)0.231
 Entry tears≥2, n (%)14 (8%)12 (8%)2 (5%)0.738
Laboratory tests on admission
 UA (umol/L)386 ± 118371 ± 111446 ± 123< 0.001
 Creatinine (umol/L)85 (69–117)84 (68–108)111 (77–142)0.004
 BUN (mmol/L)6.80 (5.40–8.16)6.66 (5.27–8.00)7.19 (6.31–9.26)0.048
 D-dimer (ug/mL FEU)8.7 (3.8–18.2)7.6 (3.5–16.0)17.9 (7.8–38.2)< 0.001
 Fibrinogen (g/L)2.18 (1.51–3.03)2.36 (1.67–3.10)1.76 (1.16–2.54)0.002
 Platelet (109/L)166 (134–198)171 (139–202)153 (115–176)0.005
 WBC (109/L)13.4 (10.7–16.0)13.2 (10.6–15.7)14.0 (10.9–16.9)0.134
Organ ischemia, n (%)
 Brain10 (5%)7 (5%)3 (8%)0.450
 Coronary artery involvement37 (20%)27 (18%)10 (25%)0.361
 Lower limb45 (24%)31 (21%)14 (35%)0.072
 eGFR< 60 ml/min/1.73 m249 (26%)31 (21%)18 (45%)0.003
Operation profiles
 Extent of aortic replacement, n (%)    
 Total arch replacement106 (57%)76 (52%)30 (75%)0.009
  Hemiarch replacement18 (10%)15 (10%)3 (8%)0.823
  Ascending aortic replacement62 (33%)55 (38%)7 (17%)0.016
Bentall, n (%)63 (34%)50 (34%)13 (33%)0.836
Operation time (min)424 (354–520)406 (343–475)540 (455–649)< 0.001
CPB time (min)200 (167–242)195 (162–227)238 (198–333)< 0.001
ACC time (min)146 (121–187)141 (119–179)166 (138–208)0.012
HCA time (min)31 (0–41)30 (0–40)36 (29–46)0.001
  1. Data are represented as median (interquartile range), n(%), or mean ± SD
  2. The bold values indicate statistical significance
  3. CKD chronic kidney disease, eGFR estimated glomerular filtration rate, UA uric acid, BUN blood urea nitrogen, WBC white blood cell count, CPB cardiopulmonary bypass, ACC aortic cross-clamping, HCA hypothermic circulatory arrest