Table 1 Baseline characteristics of patients with AADA and hypoxemia within 24 h after surgery: pre-PSM
Variable | Control (N = 136) | iNO treatment (N = 40) | p-value |
|---|---|---|---|
Age, y | 50.4 ± 11.0 | 49.9 ± 11.2 | 0.789 |
Men | 110 (80.9) | 31 (77.5) | 0.638 |
BMI | 26.5 ± 2.7 | 26.3 ± 2.9 | 0.707 |
Comorbidity | |||
Hypertension | 96 (70.6) | 32 (80.0) | 0.240 |
Diabetes | 2 (1.5) | 2 (5.0) | 0.476 |
COPD | 3 (2.2) | 1 (2.5) | 1.000 |
Hepatic insufficiency | 4 (2.9) | 1 (2.5) | 1.000 |
Renal insufficiency | 27 (19.9) | 12 (30.0) | 0.174 |
Cerebrovascular event | 3 (2.2) | 2 (5.0) | 0.694 |
Myocardial infarction | 9 (6.6) | 2 (5.0) | 1.000 |
tamponade | 21 (15.4) | 9 (22.5) | 0.297 |
Marfan Syndrome | 6 (4.4) | 3 (7.5) | 0.711 |
Smoking | 32 (23.5) | 8 (20.0) | 0.640 |
Laboratory test | |||
Leucocyte (109/L) | 12.0 ± 4.0 | 13.0 ± 3.4 | 0.147 |
Hemoglobin (g/L) | 132.0 (123.0, 143.0) | 137.5 (124.8, 150.3) | 0.112 |
Platelet (109/L) | 147.0 (121.3, 201.8) | 161.5 (140.5, 200.0) | 0.317 |
ALT (U/L) | 26.5 (19.3, 38.0) | 30.5 (19.0, 41.4) | 0.930 |
Creatinine (μmol/L) | 85.0 (68.0, 107.8) | 89.5 (70.3, 132.0) | 0.437 |
Troponin I (ng/ml) | 0.02 (0.01, 0.05) | 0.02 (0.01, 0.09) | 0.782 |
PaO2 (mmHg) | 85.5(71.2, 101.7) | 80.0(67.7, 109.2) | 0.897 |
Surgical procedure | |||
Total arch replacement | 129 (94.9) | 38 (95.0) | 1.000 |
Hemi arch replacement | 7 (5.1) | 2 (5.0) | 1.000 |
Concomitant CABG | 10 (7.4) | 2 (5.0) | 1.000 |
CPB | |||
CPB time (min) | 167.5 (143.5, 186.8) | 162.5 (147.0, 191.5) | 0.806 |
ACC time (min) | 97.5 (84.0, 109.8) | 96.0 (87.3, 117.3) | 0.604 |
DHCA time (min) | 28.0 (22.0, 31.8) | 24.0 (19.0, 28.0) | 0.041* |
Minimum temperature in CPB (°C) | 22.3 (22.1, 24.4) | 22.1 (21.5, 23.5) | 0.040* |
PaO2/FiO2 ratio meet hypoxemia criteria | 112.9 (94.3, 155.0) | 95.0 (82.9, 127.1) | 0.076 |