TY - JOUR AU - Khoshbin, Espeed AU - Spencer, Sally AU - Solomon, Laurence AU - Tang, Augustine AU - Clark, Stephen AU - Stokes, Elizabeth AU - Wordsworth, Sarah AU - Dabner, Lucy AU - Edwards, Julia AU - Reeves, Barnaby AU - Rogers, Chris PY - 2021 DA - 2021/03/26 TI - Is there a renoprotective value to leukodepletion during heart valve surgery? A randomized controlled trial (ROLO) JO - Journal of Cardiothoracic Surgery SP - 58 VL - 16 IS - 1 AB - Acute Kidney Injury (AKI) adversely affects outcomes after cardiac surgery. A major mediator of AKI is the activation of leukocytes through exposure to the cardiopulmonary bypass circuit. We evaluate the use of leukodepletion filters throughout bypass to protect against post-operative AKI by removing activated leukocytes during cardiac surgery. SN - 1749-8090 UR - https://doi.org/10.1186/s13019-021-01402-4 DO - 10.1186/s13019-021-01402-4 ID - Khoshbin2021 ER -