Table 1 Complication rates of talc insufflation for MPEs
Complication | Number of studies | Number of cases | Total patients | Incidence [95% CI] | p-value |
|---|---|---|---|---|---|
Pain | 8 | 165 | 1378 | 20 [8, 37] | < 0.001 |
Fever | 11 | 190 | 1574 | 14 [7, 23] | < 0.001 |
Pneumothorax | 3 | 29 | 461 | 6 [1, 14] | < 0.001 |
Pneumonia | 6 | 52 | 1058 | 4 [0, 12] | 0.02 |
Emphysema | 6 | 54 | 1577 | 3 [1, 7] | < 0.001 |
Prolonged air leakage | 5 | 57 | 1661 | 3 [0, 7] | 0.01 |
Prolonged drainage | 2 | 26 | 823 | 3 [2, 4] | < 0.001 |
Thromboembolism | 2 | 17 | 496 | 3 [2, 5] | < 0.001 |
Nausea/vomiting | 3 | 5 | 234 | 2 [0, 5] | 0.04 |
Respiratory insufficiency | 3 | 5 | 178 | 2 [0, 5] | 0.02 |
Hypotension | 2 | 5 | 188 | 2 [0, 5] | 0.01 |
Lung injury | 3 | 11 | 704 | 2 [1, 3] | < 0.001 |
Pulmonary embolism | 4 | 14 | 828 | 2 [0, 4] | 0.02 |
Arrythmia | 6 | 20 | 828 | 2 [0, 4] | < 0.001 |
Empyema | 11 | 28 | 1883 | 1 [0, 2] | < 0.001 |
Wound infection | 5 | 15 | 1240 | 1 [0, 2] | < 0.001 |
Renal dysfunction | 2 | 6 | 401 | 1 [0, 3] | < 0.001 |
Re-expansion pulmonary edema | 5 | 18 | 1188 | 1 [0, 3] | 0.01 |
Respiratory failure | 7 | 13 | 1863 | 0 [0, 1] | 0.24 |
Acute respiratory distress syndrome | 14 | 27 | 2889 | 0 [0, 1] | 0.36 |
Bleeding | 7 | 13 | 2148 | 0 [0, 1] | < 0.001 |
Tumor recurrence at port | 2 | 4 | 428 | 0 [0, 1] | 0.17 |
Myocardial infarction | 3 | 5 | 1253 | 0 [0, 1] | < 0.001 |
Pulmonary edema | 3 | 3 | 561 | 0 [0, 2] | 0.44 |