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Table 3 Comparison between patients with and without late RVF

From: Impact of tricuspid regurgitation on late right ventricular failure in left ventricular assist device patients ~can prophylactic tricuspid annuloplasty prevent late right ventricular failure? ~

 

no late RVF

late RVF

Univariable analysis

p value

Multivariable analysis

p value

(n = 131)

(n = 16)

HR (95% CI)

HR (95% CI)

Etiology

 DCM, n(%)

82 (63%)

7 (44%)

0.38 (0.13–1.06)

0.06

  

 dHCM, n(%)

15 (11%)

7 (44%)

5.11 (1.79–14.2)

0.0032*

2.89 (0.87–9.15)

0.08

 ICM, n(%)

15 (11%)

0 (0%)

0.07

  

 pacing device, n(%)

67 (52%)

13 (81%)

3.77 (1.21–16.5)

0.02*

3.75 (1.11–17.8)

0.03*

TR worsening during LVAD

 (except for TR worsening after RVF)

6 (5%)

0 (0%)

0.28

  

Pre-LVAD UCG

 LVDd (mm)

70.4 ± 12.1

63.3 ± 15.7

0.95 (0.91–0.99)

0.01*

0.87 (0.69–1.08)

0.20

 LVDs (mm)

65.0 ± 12.8

57.0 ± 17.8

0.96 (0.92–0.99)

0.01*

1.10 (0.89–1.36)

0.38

 LVEF (%)

20.1 ± 8.1

25.6 ± 11.0

1.06 (1.01–1.11)

0.02*

1.03 (0.94–1.12)

0.55

 RVDd (mm)

39.8 ± 10.1

41.0 ± 9.0

1.01 (0.96–1.07)

0.62

  

 TAPSE (mm/s)

14.5 ± 4.7

12.7 ± 4.3

0.92 (0.80–1.04)

0.19

  

 TRPG (mmHg)

32.0 ± 14.0

27.6 ± 13.4

0.96 (0.91–1.00)

0.07

  

Pre-LVAD RHC

 PAP systolic (mmHg)

40.0 ± 13.3

39.6 ± 15.3

0.98 (0.95–1.02)

0.39

  

 PAP diastolic (mmHg)

19.8 ± 7.9

19.0 ± 8.9

0.97 (0.91–1.03)

0.30

  

 PAP mean (mmHg)

27.8 ± 9.6

27.6 ± 11.1

0.98 (0.93–1.03)

0.39

  

 PCWP (mmHg)

20.1 ± 8.3

19.8 ± 10.5

0.97 (0.92–1.03)

0.37

  

 RAP (mmHg)

7.6 ± 4.8

9.6 ± 4.8

1.07 (0.97–1.17)

0.18

  

 CI(L/min/m2)

2.25 ± 0.80

2.26 ± 0.52

1.09 (0.56–1.74)

0.78

  

 RAP/PCWP

0.39 ± 0.30

0.50 ± 0.22

2.55 (0.61–6.47)

0.17

  

 PAPi

2.86 (0.55–17)

2.17 (0.81–16)

0.93 (0.74–1.10)

0.47

  

 RVSWI (mmHg×ml/m2)

537 ± 281

533 ± 277

1.00 (1.00–1.00)

0.71

  

Pre-LVAD laboratory data

 BUN (mg/dl)

19.7 ± 12.5

24.1 ± 11.4

1.02 (0.99–1.05)

0.17

  

 Cr (mg/dl)

1.04 ± 0.49

1.18 ± 0.47

1.50 (0.57–3.12)

0.38

  

 Ccr (ml/min/m2)

72.9 ± 35.3

56.7 ± 23.4

0.98 (0.96–1.00)

0.08

  

 T-Bil (mg/dl)

1.07 ± 0.77

1.02 ± 0.51

0.94 (0.38–1.76)

0.87

  

 BNP (pg/μl)

388 (30.8–4206)

561 (44–3022)

1.00 (1.00–1.00)

0.50

  
  1. BNP brain natriuretic peptide, BUN blood urea nitrogen, Ccr creatinine clearance, CI cardiac index, Cr serum creatinine, DCM dilated cardiomyopathy, dHCM dilated phase hypertrophic cardiomyopathy, HR hazard ratio, ICM ischemic cardiomyopathy, LVAD left ventricular assist device, LVDd left ventricular end-diastolic dimension, LVDs left ventricular end-systolic dimension, LVEF left ventricular ejection fraction, PAP pulmonary artery pressure, PAPi pulmonary artery pulsatility index, PCWP pulmonary capillary wedge pressure, RAP right atrial pressure, RHC right heart catheterization, RVDd right ventricular end diastolic dimension, RVF right ventricular failure, RVSWI right ventricular stroke work index, TAPSE tricuspid annular plane systolic excursion, T-Bil total bilirubin, TR tricuspid regurgitation, TRPG tricusid regurgitation peak gradient, UCG ultrasonic echocardiography