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Table 3 Univariate and multivariate analysis of factors affecting AL after esophagectomy

From: Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

Variable

Number (%)

Univariate analysis

Multivariate analysis

OR(95% CI)

p value

OR(95% CI)

p value

Age (years)

   

0.995(0.925–1.069)

0.882

BMI (kg/m2)

   

0.918(0.735–1.147)

0.453

ASA score

  

0.014

 

0.169

 1

187(68.5)

1

 

1

 

 2

72(26.4)

0.150(0.035–0.643)

 

0.143(0.017–1.182)

 

 3

14(5.1)

0.872(0.186–4.097)

 

0.421(0.033–5.439)

 

Operation type

  

0.006

 

0.246

 Open operation

137(50.2)

1

 

1

 

 VATS

97(35.5)

3.694(1.601–8.522)

 

2.656(0.540–13.073)

 

 RATS

39(14.3)

2.092(0.658–6.650)

 

0.693(0.103–4.686)

 

Duration of operation (hours)

  

0.000

 

0.020

 <3.7

127(46.5)

1

 

1

 

 ≥ 3.7

146(53.5)

17.544(4.111–74.861)

 

9.363(1.416–61.909)

 

Postoperative WBC (109/L)

  

0.870

 

0.145

 <9.5

85(31.1)

1

 

1

 

 ≥ 9.5

188(68.9)

0.938(0.435–2.023)

 

0.318(0.068–20.532)

 

Postoperative RBC (1012/L)

  

0.114

 

0.155

 <4.0

134(49.1)

1

 

1

 

 ≥ 4.0

139(50.9)

0.555(0.266–1.160)

 

3.562(0.618–20.532)

 

Postoperative Hb (g/L)

  

0.001

 

0.121

 <120

130(47.6)

1

 

1

 

 ≥ 120

143(52.4)

0.282(0.126–0.630)

 

0.246(0.042–1.446)

 

Postoperative glucose (mmol/L)

   

0.945(0.772–1.156)

0.582

Postoperative CRP/ALB ratio

  

0.000

 

< 0.001

 <3.00

220(80.6)

1

 

1

 

 ≥ 3.00

53(19.4)

70.435(22.790–217.687)

 

102.909(22.522–470.224)

 

Postoperative NLR

  

0.088

 

0.788

 <18.38

165(60.4)

1

 

1

 

 ≥ 18.38

108(39.6)

1.863(0.904–3.836)

 

1.318(0.176–9.874)

 

Postoperative PLR

  

0.015

 

0.254

 <255.00

117(42.9)

1

 

1

 

 ≥ 255.00

156(57.1)

2.725(1.186–6.264)

 

2.818(0.476–16.689)

 

Postoperative LMR

  

0.070

 

0.851

 <1.04

129(47.3)

1

 

1

 

 ≥ 1.04

144(52.7)

0.510(0.244–1.067)

 

0.843(0.142–5.024)

 

Postoperative PNI

  

0.008

 

0.856

 <58.90

90(33.0)

1

 

1

 

 ≥ 58.90

183(67.0)

0.383(0.185–0.794)

 

1.219(0.125–11.888)

 
  1. Data are presented as n (%)
  2. OR odds ratio, CI confidence interval, BMI body mass index, ASA score American Society of Anesthesiologists (ASA) score, VATS video-assisted thoracic surgery, RATS robot-assisted thoracic surgery, WBC white blood cell, RBC red blood cell, Hb hemoglobin, CRP/ALB ratio C-reactive protein to albumin ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, LMR lymphocyte to monocyte ratio, PNI prognostic nutritional index
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