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Table 1 List and targets/pathways of miRNAs in myocardial I/R injury

From: Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

miRNA Change in expression Downstream targets/pathways Study
miR-204 downregulation increase of LC3-II expression [45, 46]
miR-30e downregulation increase of LC3B-II, Beclin-1 and p62 level [47]
miR-221 upregulation decrease of LC3-II expression [48, 49]
miR-142-3p downregulation increase of percent of cells positive for LC3 Avs, and the level of LC3-II/LC3-I ratio, Beclin-1 and p62 [54]
miR-30a downregulation decrease of ULK1 and Beclin-1, and mediated by PI3K/Akt signaling axis [55, 56, 67]
miR181a-1 downregulation decrease of Beclin-1 expression [57]
miR139-3p downregulation decrease of Beclin-1 expression [57]
miR-325 upregulation A E2F1/miR-325/ARC signaling axis modulating autophagy [59]
miR-34a downregulation decrease of LC3-II, p62 and autophagy level [60]
miR-429 upregulation decrease in the number of GFP-LC3B labelled cells, vesicle and autophagosome, increase of the level of LC3BI/II, p62 and ATG13 [61]
miR-497 downregulation decrease of autophagic flux, and increase of LC3B-II level [62]
miR-638 downregulation increase of autophagy via targeting ATG5 [63]
miR-431 downregulation decrease of ATG3 expression [64]
miR-29c upregulation decrease of autophagy by targeting the PTEN/AKT/mTOR signal pathway [65]
let-7b downregulation decrease of Beclin-1, Atg5, Atg7 and Atg12 expression [66]
miR-384 downregulation increase of autophagosomes and autophagic flux, the activation of PI3K/Akt pathway [68]
miR-17-3p upregulation increase of LC3II/LC3I level [69]