Table 1 List and targets/pathways of miRNAs in myocardial I/R injury

miR-204

downregulation

increase of LC3-II expression

[45, 46]

miR-30e

downregulation

increase of LC3B-II, Beclin-1 and p62 level

[47]

miR-221

upregulation

decrease of LC3-II expression

[48, 49]

miR-142-3p

downregulation

increase of percent of cells positive for LC3 Avs, and the level of LC3-II/LC3-I ratio, Beclin-1 and p62

[54]

miR-30a

downregulation

decrease of ULK1 and Beclin-1, and mediated by PI3K/Akt signaling axis

[55, 56, 67]

miR181a-1

downregulation

decrease of Beclin-1 expression

[57]

miR139-3p

downregulation

decrease of Beclin-1 expression

[57]

miR-325

upregulation

A E2F1/miR-325/ARC signaling axis modulating autophagy

[59]

miR-34a

downregulation

decrease of LC3-II, p62 and autophagy level

[60]

miR-429

upregulation

decrease in the number of GFP-LC3B labelled cells, vesicle and autophagosome, increase of the level of LC3BI/II, p62 and ATG13

[61]

miR-497

downregulation

decrease of autophagic flux, and increase of LC3B-II level

[62]

miR-638

downregulation

increase of autophagy via targeting ATG5

[63]

miR-431

downregulation

decrease of ATG3 expression

[64]

miR-29c

upregulation

decrease of autophagy by targeting the PTEN/AKT/mTOR signal pathway

[65]

let-7b

downregulation

decrease of Beclin-1, Atg5, Atg7 and Atg12 expression

[66]

miR-384

downregulation

increase of autophagosomes and autophagic flux, the activation of PI3K/Akt pathway

[68]

miR-17-3p

upregulation

increase of LC3II/LC3I level

[69]