Table 2 List and targets/pathways of lncRNAs in myocardial I/R injury

MALAT1

upregulation

a MALAT1/miR-204/LC3-II signaling axis to regulate autophagy

[70, 71]

TUG1

upregulation

increase of percent of cells containing LC3+ AVs, and the expression of LC3-I, LC3-II, Beclin-1 and p62

[54]

PVT1

upregulation

increase of expression levels of LC3-II and Beclin-1, the decrease of expression of p62 and the accumulation of autophagic vacuoles

[72]

CAIF

downregulation

inhibition cardiac autophagy via a CAIF-p53-myocardin signaling axis

[73]

Neat1

upregulation

promoting myocardial autophagy via upregulation of Foxo1

[74, 79]

APF

upregulation

modulating autophagy via APF/miR-188-3p/ATG7 signaling axis

[75]

Dancr

downregulation

increase of the level of Beclin 1 and LC3II/I ratio, and the decrease of the expression of p62

[76]

TTTY15

upregulation

inhibition of autophagythrough targeting miR-374a-5p

[77]

HRIM

upregulation

reduction of autophagy

[78]

AK088388

upregulation

increase of Beclin-1, and LC3-II expression

[80]

RMRP

upregulation

a RMPR/miR-206/ATG3 axis involved in autophagy via activation of PI3K/Akt/mTOR pathway

[81]

FOXD3-AS1

upregulation

increase of level of LC3 II, Beclin1, ATG5, and reduced the expression of p62, mediated by NF-κB/iNOS/COX2 axis

[82]

AK139328

upregulation

increase of the level of LC3-I/LC3-II, ATG5, ATG7 and p62

[83]

UCA1

upregulation

reduction of cell autophage

[84]