Variables | Overall survival | Lung cancer-specific survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariable Cox regression | Univariate analysis | Multivariable Cox regression | |||||
HR (95%) | p | HR (95%) | p | HR (95%) | p | HR (95%) | p | |
Age | ||||||||
≤ 60 y | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
60–70 y | 1.569 (1.286 to 1.913) | < 0.001 | 1.420 (1.161 to 1.737) | < 0.001 | 1.224 (0.949 to 1.578) | 0.905 | 1.139 (0.880 to 1.474) | 0.325 |
> 70 y | 2.853(2.285 to 3.562) | < 0.001 | 2.442 (1.943 to 3.068) | < 0.001 | 1.984 (1.476 to 2.669) | < 0.001 | 1.753 (1.291 to 2.380) | < 0.001 |
Gender | ||||||||
Male | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Female | 0.666 (0.577 to 0.767) | < 0.001 | 0.732 (0.633 to 0.846) | < 0.001 | 0.707 (0.580 to 0.862) | < 0.001 | 0.773 (0.632 to 0.945) | 0.013 |
Race | ||||||||
White | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Black | 1.053 (0.811 to 1.367) | 0.702 | 1.134 (0.871 to 1.475) | 0.352 | 1.055 (0.736 to 1.513) | 0.772 | 1.077 (0.749 to 1.548) | 0.692 |
Hispanic | 0.471 (0.273 to 0.813) | 0.007 | 0.471 (0.272 to 0.814) | 0.007 | 0.558 (0.278 to 1.120) | 0.102 | 0.556 (0.276 to 1.120) | 0.102 |
Asian | 0.418 (0.251 to 0.696) | 0.001 | 0.454 (0.272 to 0.756) | 0.003 | 0.373 (0.177 to 0.785) | 0.010 | 0.407 (0.193 to 0.858) | 0.019 |
Other | 0.607 (0.197 to 1.878) | 0.389 | 0.732 (0.236 to 2.269) | 0.591 | NA | NA | NA | NA |
Side | ||||||||
LEFT | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
RIGHT | 0.964 (0.834 to 1.114) | 0.618 | NA | NA | 0.967 (0.790 to 1.182) | 0.742 | NA | NA |
Location | ||||||||
Upper | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Middle | 0.689 (0.490 to 0.969) | 0.033 | 0.798 (0.566 to 1.126) | 0.201 | 0.686 (0.427 to 1.103) | 0.121 | 0.786 (0.487 to 1.269) | 0.786 |
Lower | 0.918 (0.781 to 1.079) | 0.299 | 0.965 (0.820 to 1.135) | 0.667 | 0.923 (0.738 to 1.155) | 0.486 | 0.979 (0.781 to 1.228) | 0.857 |
Grade | ||||||||
Grade I | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Grade II | 1.903 (1.548 to 2.338) | < 0.001 | 1.505 (1.211 to 1.870) | < 0.001 | 2.423 (1.786 to 3.287) | < 0.001 | 2.036 (1.483 to 2.795) | < 0.001 |
Grade III | 2.373 (1.904 to 2.958) | < 0.001 | 1.640 (1.291 to 2.084) | < 0.001 | 2.859 (2.064 to 3.959) | < 0.001 | 2.089 (1.474 to 2.960) | < 0.001 |
Grade IV | 1.704 (0.965 to 3.010) | 0.068 | 1.000 (0.524 to 1.907) | 0.999 | 1.886 (0.814 to 4.369) | 0.141 | 0.948 (0.374 to 2.407) | 0.912 |
Unknow | 1.896 (1.459 to 2.464) | < 0.001 | 1.806 (1.379 to 2.365) | < 0.001 | 2.584 (1.784 to 3.744) | < 0.001 | 2.524 (1.723 to 3.697) | < 0.001 |
Histology | ||||||||
sq | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
ad | 0.598 (0.535 to 0.670) | < 0.001 | 0.751 (0.628 to 0.898) | 0.002 | 0.777 (0.606 to 0.996) | 0.048 | 0.994 (0.767 to 1.287) | 0.963 |
BAC | 0.350 (0.269 to 0.451) | < 0.001 | 0.479 (0.357 to 0.641) | < 0.001 | 0.378 (0.254 to 0.560) | < 0.001 | 0.530 (0.344 to 0.815) | 0.004 |
Large cell | 0.947 (0.643 to 1.395) | 0.786 | 1.110 (0.718 to 1.718) | 0.640 | 1.462 (0.892 to 2.395) | 0.134 | 1.793 (1.038 to 3.097) | 0.037 |
Other | 0.820 (0.637 to 1.056) | 0.127 | 0.858 (0.660 to 1.117) | 0.258 | 1.046 (0.731 to 1.496) | 0.806 | 1.083 (0.746 to 1.571) | 0.677 |
Surgical type | ||||||||
Lobectomy | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Segmentectomy | 1.046 (0.745 to 1.469) | 0.795 | 0.817 (0.565 to 1.180) | 0.286 | 1.121 (0.710 to 1.770) | 0.625 | 0.891 (0.540 to 1.469) | 0.652 |
Wedge resection | 1.593 (1.375 to 1.846) | < 0.001 | 1.255 (1.022 to 1.540) | 0.031 | 1.587 (1.293 to 1.947) | < 0.001 | 1.292 (0.972 to 1.718) | 0.079 |
Lymph node | ||||||||
LND | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | 1.000 (reference) | ||||
Without LND | 1.260 (1.170 to 1.356) | < 0.001 | 1.143 (1.030 to 1.268) | 0.012 | 1.590 (1.296 to 1.953) | < 0.001 | 1.134 (0.982 to 1.310) | 0.088 |