Table 5 Multivariable cox regression for overall survival and lung cancer-specific survival in patients with non-small-cell lung cancer ≤1 cm

 ≤ 60 y

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 60–70 y

1.622 (1.480 to 1.779)

< 0.001

1.531 (1.395 to 1.680)

< 0.001

1.408 (1.252 to 1.584)

< 0.001

1.350 (1.199 to 1.520)

< 0.001

 > 70y

2.793 (2.534 to 3.080)

< 0.001

2.566 (2.323 to 2.835)

< 0.001

1.957 (1.720 to 2.228)

< 0.001

1.836 (1.609 to 2.096)

< 0.001

 Male

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 Female

0.683 (0.643 to 0.725)

< 0.001

0.722 (0.679 to 0.767)

< 0.001

0.731 (0.674 to 0.795)

< 0.001

0.772 (0.710 to 0.839)

< 0.001

 White

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 Black

0.990 (0.881 to 1.111)

0.860

1.069 (0.951 to 1.200)

0.266

0.988 (0.844 to 1.157)

0.882

1.030 (0.879 to 1.207)

0.718

 Hispanic

0.798 (0.676 to 0.942)

0.081

0.917 (0.776 to 1.082)

0.307

0.803 (0.640 to 1.007)

0.058

0.898 (0.715 to 1.127)

0.355

 Asian

0.598 (0.508 to 0.703)

< 0.001

0.682 (0.580 to 0.803)

0.002

0.609 (0.488 to 0.760)

< 0.001

0.695 (0.557 to 0.869)

0.001

 Other

0.760 (0.473 to 1.222)

0.260

0.843 (0.524 to 1.355)

0.482

0.751 (0.392 to 1.442)

0.393

0.820 (0.427 to 1.574)

0.552

 LEFT

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 RIGHT

0.978 (0.920 to 1.040)

0.486

NA

NA

0.980 (0.902 to 1.067)

0.649

NA

NA

 Upper

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 Middle

0.846 (0.738 to 0.970)

0.017

0.905 (0.789 to 1.038)

0.155

0.822 (0.681 to 0.993)

0.043

0.892 (0.738 to 1.079)

0.241

 Lower

0.986 (0.922 to 1.054)

0.683

1.019 (0.953 to 1.089)

0.587

0.968 (0.883 to 1.061)

0.488

1.017 (0.927 to 1.114)

0.726

 Grade I

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 Grade II

1.790 (1.630 to 1.967)

< 0.001

1.505 (1.364 to 1.661)

< 0.001

1.987 (1.737 to 2.273)

< 0.001

1.753 (1.524 to 2.015)

< 0.001

 Grade III

2.334 (2.115 to 2.574)

< 0.001

1.793 (1.613 to 1.992)

< 0.001

2.705 (2.353 to 3.109)

< 0.001

2.215 (1.909 to 2.569)

< 0.001

 Grade IV

2.435 (1.913 to 3.099)

< 0.001

1.447 (1.105 to 1.896)

0.008

2.709 (1.939 to 3.785)

< 0.001

1.695 (1.170 to 2.456)

0.006

 Unknow

1.744 (1.520 to 2.001)

< 0.001

1.623 (1.411 to 1.868)

< 0.001

2.042 (1.688 to 2.470)

< 0.001

1.938 (1.596 to 3.353)

< 0.001

 sq

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 ad

0.590 (0.550 to 0.633)

< 0.001

0.775 (0.720 to 0.834)

< 0.001

0.731 (0.661 to 0.807)

< 0.001

0.953 (0.860 to 1.057)

0.364

 BAC

0.353 (0.313 to 0.398)

< 0.001

0.514 (0.451 to 0.586)

< 0.001

0.399 (0.336 to 0.474)

< 0.001

0.613 (0.509 to 0.738)

< 0.001

 Large cell

1.118 (0.954 to 1.309)

0.170

1.197 (1.003 to 1.428)

0.048

1.370 (1.105 to 1.696)

0.004

1.403 (1.107 to 1.780)

0.005

 Other

0.736 (0.657 to 0.825)

< 0.001

0.854 (0.760 to 0.960)

0.009

0.876 (0.748 to 1.026)

0.102

0.984 (0.837 to 1.157)

0.847

 Lobectomy

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 segmentectomy

1.290 (1.129 to 1.476)

< 0.001

1.094 (0.945 to 1.267)

0.231

1.205 (0.998 to 1.456)

0.054

1.051 (0.856 to 1.290)

0.636

 Wedge resection

1.832 (1.710 to 1.962)

< 0.001

1.499 (1.371 to 1.640)

< 0.001

1.825 (1.663 to 2.004)

< 0.001

1.543 (1.365 to 1.744)

< 0.001

 LND

1.000 (reference)

1.000 (reference)

1.000 (reference)

1.000 (reference)

 Without LND

1.213 (1.177 to 1.251)

< 0.001

1.066 (1.024 to 1.110)

0.002

1.212 (1.163 to 1.263)

< 0.001

1.072 (1.014 to 1.133)

0.015