The D-dimer level predicts the prognosis in patients with lung cancer: a systematic review and meta-analysis

Table 2 results of meta-analyses of prediction value

Survival outcome	No	HR [95% CI]	Log-rank p	Heterogeneity (p, I2(%))	Publication bias
OS	27	1.742(1.542,1.969)	< 0.001	< 0.001,72.1%	0.871
location
Asia	20	1.979(1.646,2.379)	< 0.001	< 0.001,75.3%
Europe	3	1.504(1.335,1.695)	< 0.001	0.623,0.0%
Oceania	2	1.572(0.899,2.746)	0.112	0.111,60.6
Histology type (adenocarcinoma/total > 25%)
Yes	8	1.639(1.298,2.069)	< 0.001	< 0.001,71.8%
No	15	1.976(1.651,2.364)	< 0.001	< 0.001,75.3%
Tumor stage (III + IV/total > 80%)
Yes	9	1.681(1.377,2.053)	< 0.001	< 0.001,78.0%
No	8	1.352(1.265,1.445)	< 0.001	0.065,47.4%
Detection method
ELISA	7	2.144(1.466,3.134)	< 0.001	< 0.001,74.4%
latex assay	4	1.513(1.266,1.810)	< 0.001	0.026,67.6%
immunoturbidimetry assay	10	1.363(1.264,1.470)	< 0.001	0.065,44.1%
Surgery
Non-surgical	8	2.380(1.78,3.18)	< 0.001	0.019,58.2%
surgical	4	1.910(1.17,3.14)	< 0.001	0.008,74.5%
mixed	5	1.688(1.333,2.139)	< 0.001	0.020,65.6%
PFS	7	1.385(1.169,1.641)	< 0.001	0.003,69.1%
location
Asia	6	1.461(1.148,1.861)	0.002	0.007,68.5%
Europe	1	1.340(1.167,1.539)	< 0.001
Histology type (adenocarcinoma/total > 25%)
Yes	1	1.340(1.167,1.539)	< 0.001
No	6	1.461(1.148,1.861)	0.002	0.007,68.5%
Tumor stage (III + IV/total > 80%)
Yes	3	1.431(1.022,2.004)	0.037	0.005,81.1%
No	1	2.400(1.413,4.078)	0.001
Detection method
latex assay	1	1.340(1.167,1.539)	< 0.001
immunoturbidimetry assay	6	1.461(1.148,1.861)	0.002	0.007,68.5%%
Surgery
Non-surgical	5	1.310(1.076,1.596)	0.007	0.074,53.0%
mixed	1	2.400 (1.413,4.078)	0.001

ISSN: 1749-8090