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Table 1 The detailed characteristics of the patients at baseline between the liberal and conservative oxygen therapy

From: Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials

Study Country Design Intervention Patient
Mean age SD Male Sample size Follow-up duration Spo2 Pao2
Young [10] New Zealand Multicenter LOT 58.3 ± 15 15 75 130 90 days, 180 days 96.2% ± 3% 97 ± 61.9
COT 57.2 ± 14.3 14 59 121 95.9% ± 3.7% 99 ± 50.5
Mackle [7] Australian and New Zealand Multicenter LOT 58.1 ± 16.2 16 306 484 90 days, 180 days 97.1% ± 3.1% 110 ± 69.6
COT 57.5 ± 16.1 16 302 481 96.7% ± 3.7% 112 ± 63
Barrot [9] French Multicenter LOT 63 ± 15.5 16 65 99 28 days, 90 days 90.3 ± 38.8
COT 63.5 ± 14.5 15 64 102 92.3 ± 44.8
Peters [12] UK Multicenter LOT 1.9 (0.4,5) 3.4 21 54 99% ± 2.22%
COT 0.8 (0.1,2) 1.4 29 53 99% ± 1.48%
Girardis [14] Italy Single-center LOT 65 ± 17.8 18 125 218 24 days
COT 63 ± 17 17 121 216 22 days
Panwar [13] Australia Multicenter LOT NA NA NA 52 90 days 93% ± 2% 72 ± 10
COT NA NA NA 51 97 ± 1% 95 ± 15
Suzuki [15] Australia Single-center LOT 56 ± 16 16 32 54 28 days 95.5% ± 2.44 83 ± 17
COT 59 ± 17 17 38 51 98.4% ± 1.33% 107 ± 27.4
Study Patient Type of admission to ICU
Pao2/Fio2 ratio PEEP APACHE II SAPS III SAPS II SOFA Emergency Hospital ward Surgery Others (from another ICU or hospital)
Young [10] 213 ± 118 22.7 ± 7.5 43 44 32 11
200 ± 102 22.8 ± 8.2 50 34 24 13
Mackle [7] 259 ± 146 6 ± 3.7 23.6 ± 9.3 181 107 149 41
245 ± 138 6 ± 3.7 23.3 ± 9.4 212 82 146 41
Barrot [9] 116.8 ± 47.7 6.2 ± 2.7 66.9 ± 13.7 9.3 ± 3.68
120.1 ± 53.6 6.4 ± 3.5 67.9 ± 14.4 8.9 ± 3.6
Peters [12]
-
Girardis [14] 37 (26–49) 86 132
39 (28–55) 77 139
Panwar [13]
-
Suzuki [15] 177 ± 91.1 5.2 ± 1.78 62 ± 31.9
158 ± 86.7 6.1 ± 1.85 68 ± 38.5 -
  1. LOT liberal oxygen therapy, COT conservative oxygen therapy, SD standard deviation, SpO2 arterial saturation of peripheral oxygen, PaO2 partial pressure of oxygen, PaO2/FiO2 partial pressure of oxygen/ Fraction of inspire oxygen, PEEP positive end-expiratory pressure, APACHE II The acute physiology and chronic health evaluation score-II, SAPA III The simplified acute physiology score-III, SAPA II The simplified acute physiology score-II, SOFA sequential organ failure assessment