Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials

Table 1 The detailed characteristics of the patients at baseline between the liberal and conservative oxygen therapy

Study	Country	Design	Intervention	Patient
Study	Country	Design	Intervention	Mean age	SD	Male	Sample size	Follow-up duration	Spo₂	Pao₂
Young [10]	New Zealand	Multicenter	LOT	58.3 ± 15	15	75	130	90 days, 180 days	96.2% ± 3%	97 ± 61.9
Young [10]	New Zealand	Multicenter	COT	57.2 ± 14.3	14	59	121	90 days, 180 days	95.9% ± 3.7%	99 ± 50.5
Mackle [7]	Australian and New Zealand	Multicenter	LOT	58.1 ± 16.2	16	306	484	90 days, 180 days	97.1% ± 3.1%	110 ± 69.6
Mackle [7]	Australian and New Zealand	Multicenter	COT	57.5 ± 16.1	16	302	481	90 days, 180 days	96.7% ± 3.7%	112 ± 63
Barrot [9]	French	Multicenter	LOT	63 ± 15.5	16	65	99	28 days, 90 days	–	90.3 ± 38.8
Barrot [9]	French	Multicenter	COT	63.5 ± 14.5	15	64	102	28 days, 90 days	–	92.3 ± 44.8
Peters [12]	UK	Multicenter	LOT	1.9 (0.4,5)	3.4	21	54	–	99% ± 2.22%	–
Peters [12]	UK	Multicenter	COT	0.8 (0.1,2)	1.4	29	53	–	99% ± 1.48%	–
Girardis [14]	Italy	Single-center	LOT	65 ± 17.8	18	125	218	24 days	–	–
Girardis [14]	Italy	Single-center	COT	63 ± 17	17	121	216	22 days	–	–
Panwar [13]	Australia	Multicenter	LOT	NA	NA	NA	52	90 days	93% ± 2%	72 ± 10
Panwar [13]	Australia	Multicenter	COT	NA	NA	NA	51	90 days	97 ± 1%	95 ± 15
Suzuki [15]	Australia	Single-center	LOT	56 ± 16	16	32	54	28 days	95.5% ± 2.44	83 ± 17
Suzuki [15]	Australia	Single-center	COT	59 ± 17	17	38	51	28 days	98.4% ± 1.33%	107 ± 27.4

Study	Patient						Type of admission to ICU
Study	Pao₂/Fio₂ ratio	PEEP	APACHE II	SAPS III	SAPS II	SOFA	Emergency	Hospital ward	Surgery	Others (from another ICU or hospital)
Young [10]	213 ± 118	–	22.7 ± 7.5	–	–	–	43	44	32	11
Young [10]	200 ± 102	–	22.8 ± 8.2	–	–	–	50	34	24	13
Mackle [7]	259 ± 146	6 ± 3.7	23.6 ± 9.3	–	–	–	181	107	149	41
Mackle [7]	245 ± 138	6 ± 3.7	23.3 ± 9.4	–	–	–	212	82	146	41
Barrot [9]	116.8 ± 47.7	6.2 ± 2.7	–	66.9 ± 13.7	–	9.3 ± 3.68	–	–	–	–
Barrot [9]	120.1 ± 53.6	6.4 ± 3.5	–	67.9 ± 14.4	–	8.9 ± 3.6	–	–	–	–
Peters [12]	–	–	–	–	–	–	–	–	–	–
Peters [12]	–	–	–	–	–	-	–	–	–	–
Girardis [14]	–	–	–	–	37 (26–49)	–	–	86	132	–
Girardis [14]	–	–	–	–	39 (28–55)	–	–	77	139	–
Panwar [13]	–	–	–	–	–	–	–	–	–	–
Panwar [13]	–	–	–	–	–	–	–	-	–	–
Suzuki [15]	177 ± 91.1	5.2 ± 1.78	62 ± 31.9	–	–	–	–	–	–	–
Suzuki [15]	158 ± 86.7	6.1 ± 1.85	68 ± 38.5	-	–	–	–	–	–	–

LOT liberal oxygen therapy, COT conservative oxygen therapy, SD standard deviation, SpO₂ arterial saturation of peripheral oxygen, PaO₂ partial pressure of oxygen, PaO₂/FiO₂ partial pressure of oxygen/ Fraction of inspire oxygen, PEEP positive end-expiratory pressure, APACHE II The acute physiology and chronic health evaluation score-II, SAPA III The simplified acute physiology score-III, SAPA II The simplified acute physiology score-II, SOFA sequential organ failure assessment

ISSN: 1749-8090