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Table 1 The detailed characteristics of the patients at baseline between the liberal and conservative oxygen therapy

From: Liberal or conservative oxygen therapy for ventilated patients in the ICU: a meta-analysis of randomized controlled trials

Study

Country

Design

Intervention

Patient

Mean age

SD

Male

Sample size

Follow-up duration

Spo2

Pao2

Young [10]

New Zealand

Multicenter

LOT

58.3 ± 15

15

75

130

90 days, 180 days

96.2% ± 3%

97 ± 61.9

COT

57.2 ± 14.3

14

59

121

95.9% ± 3.7%

99 ± 50.5

Mackle [7]

Australian and New Zealand

Multicenter

LOT

58.1 ± 16.2

16

306

484

90 days, 180 days

97.1% ± 3.1%

110 ± 69.6

COT

57.5 ± 16.1

16

302

481

96.7% ± 3.7%

112 ± 63

Barrot [9]

French

Multicenter

LOT

63 ± 15.5

16

65

99

28 days, 90 days

–

90.3 ± 38.8

COT

63.5 ± 14.5

15

64

102

–

92.3 ± 44.8

Peters [12]

UK

Multicenter

LOT

1.9 (0.4,5)

3.4

21

54

–

99% ± 2.22%

–

COT

0.8 (0.1,2)

1.4

29

53

–

99% ± 1.48%

–

Girardis [14]

Italy

Single-center

LOT

65 ± 17.8

18

125

218

24 days

–

–

COT

63 ± 17

17

121

216

22 days

–

–

Panwar [13]

Australia

Multicenter

LOT

NA

NA

NA

52

90 days

93% ± 2%

72 ± 10

COT

NA

NA

NA

51

97 ± 1%

95 ± 15

Suzuki [15]

Australia

Single-center

LOT

56 ± 16

16

32

54

28 days

95.5% ± 2.44

83 ± 17

COT

59 ± 17

17

38

51

98.4% ± 1.33%

107 ± 27.4

Study

Patient

Type of admission to ICU

Pao2/Fio2 ratio

PEEP

APACHE II

SAPS III

SAPS II

SOFA

Emergency

Hospital ward

Surgery

Others (from another ICU or hospital)

Young [10]

213 ± 118

–

22.7 ± 7.5

–

–

–

43

44

32

11

200 ± 102

–

22.8 ± 8.2

–

–

–

50

34

24

13

Mackle [7]

259 ± 146

6 ± 3.7

23.6 ± 9.3

–

–

–

181

107

149

41

245 ± 138

6 ± 3.7

23.3 ± 9.4

–

–

–

212

82

146

41

Barrot [9]

116.8 ± 47.7

6.2 ± 2.7

–

66.9 ± 13.7

–

9.3 ± 3.68

–

–

–

–

120.1 ± 53.6

6.4 ± 3.5

–

67.9 ± 14.4

–

8.9 ± 3.6

–

–

–

–

Peters [12]

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

-

–

–

–

–

Girardis [14]

–

–

–

–

37 (26–49)

–

–

86

132

–

–

–

–

–

39 (28–55)

–

–

77

139

–

Panwar [13]

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

–

-

–

–

Suzuki [15]

177 ± 91.1

5.2 ± 1.78

62 ± 31.9

–

–

–

–

–

–

–

158 ± 86.7

6.1 ± 1.85

68 ± 38.5

-

–

–

–

–

–

–

  1. LOT liberal oxygen therapy, COT conservative oxygen therapy, SD standard deviation, SpO2 arterial saturation of peripheral oxygen, PaO2 partial pressure of oxygen, PaO2/FiO2 partial pressure of oxygen/ Fraction of inspire oxygen, PEEP positive end-expiratory pressure, APACHE II The acute physiology and chronic health evaluation score-II, SAPA III The simplified acute physiology score-III, SAPA II The simplified acute physiology score-II, SOFA sequential organ failure assessment