From: The susceptibility of the aortic root: porcine aortic rupture testing under cardiopulmonary bypass
Author | Purpose | Methodology | Findings |
---|---|---|---|
Angelos et al. [4] | To determine organ blood flow changes in a swine model using CPB to achieve return of spontaneous circulation (ROSC) | Swine model of 10 pigs placed on CBP following VF cardiac arrest | Low flow cardiopulmonary bypass model produces reproducible high resuscitation rates and ROSC |
Bufalari et al. [5] | To determine the most effective practice of left pneumonectomy | Swine model of 11 pigs undergoing left pneumonectomy | The most straightforward procedure required careful dissection of the pulmonary ligament, pulmonary veins, pulmonary artery, and finally bronchus |
Eckhouse et al. [6] | To establish a reproducible model of aortic dilatation reproducing what happens in Thoracic abdominal aneurysm’s (TAA) development | Descending TAA’s were induced in 7 pigs using collagenase and crystalline and tissue analysed | Tissue demonstrates aortic dilatation, aortic medial degeneration, and alterations in MMP/TIMP abundance consistent with TAA formation |
Kofidis et al. [7] | To determine the feasibility of transapical cardioscopic surgery in a pig model | Transapical access to the ventricle was obtained in 5 pigs with right mini thoracotomy for central cannulation and CPB | Transapical approach allowed for good exposure and adequate surgical field for mitral valve, and aortic valve access, and atrial ablation and intra-aortic procedures |
Lundemeon et al. [8] | To determine the effects of pulsed and non-pulsed CPB on microvascular fluid exchange | A total of 16 pigs were randomized to pulsatile (n = 8) or non-pulsatile (n = 8) CPB | No significant differences in the fluid extravasation rates were present between pulsed and non-pulsed cardiopulmonary bypass perfusion |
Mariscal et al. [9] | To describe a surgical technique for swine lung transplantation and postoperative management 3 days postoperatively | Involved development of a protocol based on donor surgery, recipient surgery and postoperative care and sacrifice | This survival model can be used by lung researchers to assess development of primary graft dysfunction (PGD) and to test therapeutic strategies targeting PGD |
Mickelson et al. [10] | To develop an alternative to canine models in testing for cardiopulmonary bypass research | 15 pigs were divided into three groups to determine the optimum conditions during CPB to avoid complications of fluid shifts, metabolic acidosis, and hemoglobinuria | Determined that optimum blood flow rate for cardiopulmonary bypass in swine is in the range of 175–200 ml/kg min. Hyperosmolar priming solution is beneficial for CPB in swine to reduce fluid shifts, metabolic acidosis, and hemoglobinuria |
Nicols et al. [11] | To determine the effect of changing FiO2-concentration on SvO2 in a swine model on CPB | 8 mixed-gender swine were placed on CPB with an experimental and control group measuring percentage change in blood flow and oxygen delivery | Results suggest that decreased blood flow adjusting for increased SvO2 associated with high PaO2 did not result in significant reduction in adequacy of perfusion markers for organs studied |
Oizumi et al. [1] | Development of a swine model for anatomical thoracoscopic lung segmentectomy training | 33 pigs were used over a period of 5 years to train operators on segmentectomy via a hybrid (8) or thoracoscopic (23) approach. 3 pigs were converted to thoracotomy due to hemorrhage | Live swine model was considered a good choice for training surgeons on how to perform a minimally invasive lung segmentectomy in humans |
Thalmann et al. [13] | Evaluation of several hybrid approaches for pulmonary valve replacement in a swine model | 13 pigs were used using 4 different thoracotomy methods for valve implantation, and 5 cases used median sternotomy | Achieved implantation of 12/13 stented valves of which 41% were in the optimal position and 16% had paravalvular leakage. Lower partial sternotomy provided the best deemed approach |