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Table 4 Baseline comparability analysis results (ViMAC vs ViR)

From: Transcatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis

Baseline

Studies

Effect measure

Model

Participants

Effect estimate

LCI

UCI

Q

P(Q)

Z

P(Z)

Age (years)

2

Mean difference

Fixed

226

3.78

0.91

6.66

1.17

0.28

2.58

0.01

Female

4

Odds ratio

Random

489

2.21

1.11

4.40

6.80

0.08

2.24

0.02

Diabetes mellitus

4

Odds ratio

Fixed

489

1.60

1.07

2.38

2.34

0.50

2.30

0.02

Hypertension

3

Odds ratio

Fixed

266

1.78

0.96

3.30

0.26

0.88

1.83

0.07

Atrial fibrillation

3

Odds ratio

Fixed

290

0.51

0.31

0.82

2.74

0.25

2.79

0.01

Chronic kidney disease

2

Odds ratio

Fixed

263

0.98

0.59

1.63

0.62

0.43

0.09

0.93

Severe/chronic lung disease

4

Odds ratio

Random

489

1.28

0.60

2.73

7.11

0.07

0.63

0.53

Peripheral Arterial disease

3

Odds ratio

Fixed

266

1.23

0.59

2.57

0.38

0.83

0.56

0.57

Prior cerebrovascular accident

4

Odds ratio

Fixed

489

1.24

0.74

2.06

5.46

0.14

0.81

0.42

Prior percutaneous coronary intervention

1

Odds ratio

Fixed

199

0.89

0.42

1.88

0.00

1.00

0.31

0.76

Prior pacemaker

1

Odds ratio

Fixed

223

0.98

0.53

1.81

0.00

0.00

0.07

0.95

Prior aortic valve Replacement

2

          

 TAVR

2

Odds ratio

Fixed

260

9.74

2.54

37.36

0.05

0.82

3.32

< 0.01

 SAVR

2

Odds ratio

Random

262

1.11

0.19

6.45

5.40

0.02

0.11

0.91

STS risk score, %

2

Mean difference

Fixed

226

2.21

0.21

4.20

0.58

0.45

2.17

0.03

Creatinine

3

Std. mean difference

Fixed

266

0.06

− 0.20

0.33

0.45

0.80

0.48

0.63

Hemoglobin (g/dl)

2

Mean difference

Random

67

0.06

− 1.56

1.68

2.40

0.12

0.07

0.94

NT-proBNP (ng/l)

1

Mean difference

Fixed

27

− 2919

− 4825

− 1013

0.00

1.00

3.00

< 0.01

Echocardiographic parameters

3

          

 LVEF, left ventricular ejection fraction (%)

3

Mean difference

Fixed

266

13.01

9.77

16.25

0.34

0.84

7.88

< 0.01

 Mitral valve mean gradient (mmHg)

1

Mean difference

Fixed

199

4.70

3.23

6.17

0.00

1.00

6.28

< 0.01

 Right ventricular systolic pressure (mmHg)

1

Mean difference

Fixed

27

− 5.00

− 19.40

9.40

0.00

1.00

0.68

0.50

Mode of prosthesis failure

4

          

 Regurgitation

4

Odds ratio

Fixed

489

0.09

0.04

0.17

3.32

0.34

7.33

< 0.01

 Stenosis

3

Odds ratio

Random

449

7.38

1.79

30.43

13.54

0.00

2.77

0.01

 Combined

2

Odds ratio

Fixed

226

1.82

0.90

3.69

0.67

0.41

1.60

0.10

NYHA

4

          

 I/II

2

Odds ratio

Fixed

263

1.23

0.58

2.62

0.18

0.67

0.55

0.58

 III/IV

4

Odds ratio

Fixed

489

1.02

0.56

1.84

0.48

0.79

0.06

0.95