Transcatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis

You, Tao; Wang, Wei; Yi, Kang; Gao, Jie; Zhang, Xin; He, Shao-E.; Xu, Xiao-Min; Ma, Yu-Hu; Li, Xin-Yao

doi:10.1186/s13019-021-01677-7

Table 5 The results of meta-analysis of postoperative outcomes (ViV vs ViR)

From: Transcatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis

Outcomes	Studies	Effect measure	Model	Participants	Effect estimate	LCI	UCI	Q	P(Q)	Z	P(Z)
All-cause Mortality within 30 days	5	Odds ratio	Fixed	2550	0.70	0.50	0.99	0.68	0.95	2.02	*0.04*
Cardiovascular	2	Odds ratio	Fixed	933	0.59	0.29	1.18	0.47	0.49	1.49	0.14
Noncardiovascular	1	Odds ratio	Fixed	688	0.67	0.24	1.82	0.00	1.00	0.79	0.43
Unknown-cause	4	Odds ratio	Fixed	1862	0.75	0.50	1.15	1.96	0.58	1.32	0.19
Bleeding	5	Odds ratio	Random	2665	0.68	0.13	3.61	73.19	0.00	0.45	0.65
Major or extensive bleeding	4	Odds ratio	Random	2420	1.66	0.98	2.80	3.11	0.38	1.89	0.06
Life-threatening or fatal	2	Odds ratio	Random	1266	0.44	0.25	0.77	0.48	0.49	2.85	*< 0.01*
Unknown	1	Odds ratio	Random	245	14.47	0.85	245.08	0.00	0.00	1.85	0.06
Embolization	4	Odds ratio	Fixed	1577	0.34	0.12	0.98	3.57	0.31	2.00	*0.045*
Conversion to Cardiac surgery	3	Odds ratio	Fixed	1341	0.31	0.13	0.74	2.27	0.32	2.64	*0.01*
Left ventricular outflow tract obstruction	4	Odds ratio	Fixed	1586	0.22	0.11	0.44	3.07	0.38	4.31	*< 0.01*
Stroke	4	Odds ratio	Fixed	2487	3.14	0.94	10.43	0.68	0.88	1.86	0.06
Post-procedural echocardiographic findings	4
LVEF (%)	3	Mean difference	Fixed	1347	8.74	7.03	10.46	0.20	0.91	10.00	*< 0.01*
Mitral valve mean gradient (mmHg)	4	Mean difference	Fixed	1757	− 0.46	− 0.77	− 0.15	2.39	0.50	2.88	*< 0.01*
Right ventricular systolic pressure (mmHg)	1	Mean difference	Fixed	75	4.00	− 5.05	13.05	0.00	1.00	0.87	0.39
MVA, mitral valve area (cm²)	3	Mean difference	Fixed	1617	0.03	− 0.06	0.11	19.57	0.00	0.60	0.55
Vascular complication	4	Odds ratio	Random	2590	1.41	0.36	5.50	13.20	0.00	0.50	0.62
Acute kidney injury	3	Odds ratio	Fixed	1787	0.60	0.41	0.87	0.70	0.70	2.72	*0.01*
Need for second valve implantation	4	Odds ratio	Fixed	2420	0.21	0.14	0.33	0.70	0.87	7.13	*< 0.01*
Postprocedural mitral regurgitation	3
Trace/none	3	Odds ratio	Fixed	2094	3.16	2.16	4.63	4.83	0.09	5.93	*< 0.01*
1 (+)	3	Odds ratio	Fixed	2094	0.44	0.28	0.70	6.17	0.05	3.47	*< 0.01*
2 (+) or greater	3	Odds ratio	Fixed	2094	0.27	0.13	0.59	4.23	0.12	3.28	*< 0.01*

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