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Table 1 Characteristics of included studies

From: The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis

First author

Year

Country

Case (control)

Detection method

Cut-off value

TP

FP

FN

TN

Sensitivity (%)

Specificity (%)

Eggebrecht [20]

2004

Germany

16 (80)

Latex-enhanced turbidimetric test

0.626 µg/mL

16

0

58

22

100

73

Akutsu [21]

2005

Japan

30 (48)

Latex agglutination test

0.5 µg/mL

30

0

26

22

100

54

Hazui [22]

2005

Japan

29 (49)

Latex agglutination test

0.8 or 0.9 μg/ml

27

2

45

4

93.1

91.8

Ohlmann [23]

2006

France

94 (94)

Immunoturbidimetric assay

400 ng/mL

93

1

32

62

99

34

Sbarouni [24]

2007

Greece

18 (29)

ELISA

700 ng/ml

17

1

17

12

94

59

Xue [25]

2007

China

16 (27)

Immunoturbidimetric assay

0.4 µg/mL

16

0

18

9

100

66

Suzuki [26]

2009

Japan

87 (133)

Triage D-dimer test

500 ng/mL

84

3

62

71

96.6

46.6

Fan QK [27]

2010

China

107 (153)

Immunoturbidimetric assay

0.17 µg/mL

106

1

47

106

99.2

30.9

Sakamoto [28]

2011

Japan

35 (228)

Latex-enhanced turbidimetric test

5 µg/mL

24

11

206

22

68.4

90.3

Nazerian [29]

2014

Italy

233 (802)

Latex agglutination test

500 ng/ml

229

4

288

514

98.3

35.9

Peng [30]

2015

China

35 (51)

ELISA

2.11 µg/mL

28

7

46

5

80

90.21

Yoshimuta [31]

2015

Japan

9 (1227)

Latex agglutination test

6.9 μg/ml

9

0

1163

64

100

94.8

Gorla [32]

2015

Germany

159 (72)

Microparticle-enhanced immunoassay

0.5 mg/L

157

2

48

24

99

67

Sakamoto [16]

2016

Japan

5 (235)

NR

5.0 μg/ml

5

0

215

20

100

91.7

Xiao [17]

2016

China

60 (60)

Automatic coagulation instrument

1.435 mg/L

56

4

41

19

93.33

68.33

Dong [18]

2017

China

202 (150)

Immune nephelometry

NR

139

63

91

59

68.8

60.9

  1. ELISA enzyme linked immunosorbent assay, TP true positive, FP false positive, FN false negative, TN true negative, NR not reported