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Table 2 Staging and Pathologic Features

From: Comparative analysis of long-term oncologic outcomes for minimally invasive and open Ivor Lewis esophagectomy after neoadjuvant chemoradiation: a propensity score matched observational study

  

Unadjusted

IPTW adjusted

Variable

Levels

O-ILE

N = 69

M-ILE

N = 154

p-value

O-ILE

N = 68

M-ILE

N = 142

p-value

Clinical T-stage

1/2

22 (31.9%)

30 (19.5%)

0.043

21.00%

23.10%

0.731

 

3

47 (68.1%)

124 (80.5%)

 

79.00%

76.90%

 

Clinical N-stage

N0

16 (23.2%)

66 (42.9%)

0.001

41.46%

37.01%

0.868

 

N1

50 (72.5%)

71 (46.1%)

 

51.38%

56.05%

 
 

N2

3 (4.3%)

17 (11.0%)

 

7.17%

6.95%

 

Histology

Squamous Cell Carcinoma

3 (4.3%)

11 (7.1%)

0.426

3.07%

7.26%

0.166

 

Adenocarcinoma

66 (95.7%)

143 (92.9%)

 

96.93%

92.74%

 

Pathologic T-stage

T0

19 (27.5%)

41 (26.6%)

0.703

18.89%

27.22%

0.674

 

T1a/T1b

12 (17.4%)

28 (18.2%)

 

17.78%

17.71%

 
 

T2

11 (15.9%)

34 (22.1%)

 

24.09%

22.50%

 
 

T3

27 (39.1%)

51 (33.1%)

 

39.24%

32.57%

 

Pathologic N-Stage

N0/Nx

43 (62.3%)

99 (64.3%)

0.399

60.83%

66.18%

0.394

 

N1

13 (18.8%)

37 (24.0%)

 

20.31%

22.92%

 
 

N2

7 (10.1%)

12 (7.8%)

 

10.22%

7.87%

 
 

N3

6 (8.7%)

6 (3.9%)

 

8.64%

3.03%

 

Differentiation

Moderate

46 (66.7%)

74 (48.1%)

0.031

67.44%

50.42%

0.139

 

Poor

21 (30.4%)

69 (44.8%)

 

28.77%

42.68%

 
 

Well

2 (2.9%)

11 (7.1%)

 

3.79%

6.90%

 

Lymphovascular invasion

Yes

14 (20.3%)

42 (27.3%)

0.266

20.04%

27.24%

0.309

Perineural invasion

Yes

16 (23.2%)

30 (19.5%)

0.527

21.30%

19.64%

0.792

Signet ring cell features

Yes

4 (5.8%)

19 (12.3%)

0.138

9.93%

11.97%

0.741

Tumor regression grade

Complete response

18 (26.1%)

38 (24.7%)

0.043

18.60%

25.58%

0.274

 

Near complete response

24 (34.8%)

58 (37.7%)

 

42.41%

36.52%

 
 

Partial response

11 (15.9%)

42 (27.3%)

 

20.61%

27.75%

 
 

No response

16 (23.2%)

16 (10.4%)

 

18.38%

10.14%

 

Lymph nodes removed

Median [IQR]

18 [14–22]

17 [14–21]

0.956

16 [12–20]

17 [13–21]

0.822

  1. IPTW Inverse probability of treatment weighting, O-ILE Open Ivor Lewis esophagectomy, M-ILE Minimally invasive Ivor Lewis esophagectomy, IQR Interquartile range