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Table 3 Uni- and multivariate analyses of prognostic factors of recurrence after single pulmonary metastasectomy (PM)

From: Survival prognostic and recurrence risk factors after single pulmonary metastasectomy

Variables

Univariate

Multivariate

HR (95% CI)

p value

HR (95% CI)

p value

Female sex

1.02 (0.67–1.55)

0.92

  

Age < 70 years

1.84 (1.1–3.06)

0.02

1.77 (1.06–2.96)

0.03

Non-colorectal tumour

1.76 (1.09–2.84)

0.02

1.84 (1.14–2.96)

0.01

Previous extra-thoracic metastases

1.65 (1.08–2.54)

0.02

1.61 (1.05–2.47)

0.03

Chemotherapy before first PM

0.84 (0.55–1.28)

0.42

  

DFI1 < 12 months

1.29 (0.81–2.02)

0.28

  

Synchronous metastasis

1.42 (0.77–2.63)

0.26

  

VATS

1.15 (0.61–2.17)

0.66

  

Wedge resection

1.26 (0.77–2.09)

0.35

  

Margins of the pulmonary metastasis < 5 mm

1.13 (0.75–1.72)

0.54

  

Size of the pulmonary metastasis < 20 mm

0.91 (0.53–1.57)

0.74

  

Mediastinal lymph nodes involvement

1.56 (0.57–4.29)

0.39

  
  1. HR hazard ratio, CI confidence interval, PM pulmonary metastasectomy, DFI1 disease-free interval (defined as the interval between primary tumour resection and first PM), VATS Video-Assisted Thoracic Surgery