|
Variable
|
Univariable analysis
|
Multivariable analysis
|
|---|
|
Hazard ratio
|
95% CI
|
P value
|
Hazard ratio
|
95% CI
|
P value
|
|---|
|
VATS (vs. thoracotomy)
|
0.56
|
0.38
|
0.82
|
0.003
|
0.81
|
0.54
|
1.23
|
0.331
|
|
Sex, male (vs. female)
|
2.23
|
1.28
|
3.88
|
0.005
|
1.65
|
0.93
|
2.95
|
0.087
|
|
Age (per year)
|
1.05
|
1.03
|
1.08
|
< 0.001
|
1.04
|
1.02
|
1.07
|
< 0.001
|
|
CCI ≥ 2 (vs. CCI < 2)
|
2.10
|
1.34
|
3.30
|
0.001
|
1.72
|
1.09
|
2.74
|
0.021
|
|
FEV1 ≥ 80% (vs. < 80%)
|
1.02
|
0.66
|
1.56
|
0.935
| | | | |
|
DLCO ≥ 80% (vs. < 80%)
|
0.77
|
0.45
|
1.32
|
0.349
| | | | |
|
Pathologic tumor size
|
1.02
|
1.01
|
1.03
|
< 0.001
|
1.02
|
1.01
|
1.03
|
< 0.001
|
|
Pathologic N + (vs. pN0)
|
1.90
|
1.32
|
2.75
|
0.001
|
2.33
|
1.60
|
3.40
|
< 0.001
|
|
Histology (ref = ADC)
| | | |
0.009
| | | | |
|
SCC
|
1.65
|
1.16
|
2.36
| |
1.13
|
0.77
|
1.65
|
0.542
|
|
Others
|
0.87
|
0.46
|
1.66
| |
0.86
|
0.44
|
1.65
|
0.643
|
|
Adjuvant treatment
|
0.65
|
0.47
|
0.92
|
0.013
|
0.69
|
0.47
|
1.03
|
0.071
|
- Statistically significant variates (P < 0.1) in the univariable analysis were used as covariates for multivariable analysis
- VATS video-assisted thoracic surgery, CCI Charlson comorbidity index, FEV1 forced expiratory volume at 1 s, DLCO diffusing capacity for carbon monoxide, ADC adenocarcinoma, SCC squamous cell carcinoma
