Skip to main content

Table 4 Multivariable Cox proportional hazard model for OS in unmatched cohort

From: Video-assisted thoracoscopic lobectomy versus open lobectomy in the treatment of large lung cancer: propensity-score matched analysis

Variable Univariable analysis Multivariable analysis
Hazard ratio 95% CI P value Hazard ratio 95% CI P value
VATS (vs. thoracotomy) 0.56 0.38 0.82 0.003 0.81 0.54 1.23 0.331
Sex, male (vs. female) 2.23 1.28 3.88 0.005 1.65 0.93 2.95 0.087
Age (per year) 1.05 1.03 1.08  < 0.001 1.04 1.02 1.07  < 0.001
CCI ≥ 2 (vs. CCI < 2) 2.10 1.34 3.30 0.001 1.72 1.09 2.74 0.021
FEV1 ≥ 80% (vs. < 80%) 1.02 0.66 1.56 0.935     
DLCO ≥ 80% (vs. < 80%) 0.77 0.45 1.32 0.349     
Pathologic tumor size 1.02 1.01 1.03  < 0.001 1.02 1.01 1.03  < 0.001
Pathologic N + (vs. pN0) 1.90 1.32 2.75 0.001 2.33 1.60 3.40  < 0.001
Histology (ref = ADC)     0.009     
SCC 1.65 1.16 2.36   1.13 0.77 1.65 0.542
Others 0.87 0.46 1.66   0.86 0.44 1.65 0.643
Adjuvant treatment 0.65 0.47 0.92 0.013 0.69 0.47 1.03 0.071
  1. Statistically significant variates (P < 0.1) in the univariable analysis were used as covariates for multivariable analysis
  2. VATS video-assisted thoracic surgery, CCI Charlson comorbidity index, FEV1 forced expiratory volume at 1 s, DLCO diffusing capacity for carbon monoxide, ADC adenocarcinoma, SCC squamous cell carcinoma