Reference, years, country of origin | Number of patients | Mean age | Gender (F/M) | Surgery | Interventions | CPB time (min) | Adverse effects | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UTI group | Control group | UTI group | Control group | UTI group | Control group | UTI group | Control group | UTI group | Control group | ||||
Zhang et al. 2020 China | 142 | 141 | 49.0 ± 14.3 | 50.3 ± 12.4 | 63/79 | 71/70 | Open heart surgery | 1,000,000 U iv, the half after anesthesia induction and the rest prime into CPB | Equivalent normal saline | 102.87 ± 42.7 | 98.69 ± 47.76 | No | |
Xu et al. 2017 China | 20 | 20 | 53.4 ± 5.2 | 53.2 ± 5.1 | 12/8 | 13/7 | Open heart surgery | 5000 U/kg iv before CPB and at 1–3 days postoperatively | Equivalent normal saline | Unclear | No | ||
Wang et al. 2016 China | 36 | 30 | 48.4 ± 11.3 | 49.3 ± 11.7 | 32/4 | 26/4 | AAR | 300,000 U/8 h iv before 3 days postoperatively and 300,000 U/2 h during surgery | NR | 228.6 ± 69.1 | 22.4 ± 62.5 | No | |
Pang et al. 2015 China | 30 | 30 | 53.5 ± 9.8 | 50.2 ± 9.1 | 15/15 | 21/9 | Open heart surgery | 5000 U/Kg iv after anesthesia induction | Equivalent normal Saline | 215.3 ± 57.9 | 221.6 ± 76.1 | No | |
Xu et al. 2013 China | 18 | 18 | 54.8 ± 8.9 | 53.2 ± 7.3 | 16/2 | 15/3 | AAR | 20,000 U/Kg iv after anesthesia induction | Equivalent placebo | 235.5 ± 25.9 | 247.2 ± 20.3 | No | |
Hao et al. 2013 China | 20 | 20 | 56.36 ± 10.81 | 54.27 ± 10.90 | 22/18 | MVR, DVR, AVR | 1000 U/Kg iv during the preoperative period | NR | 98.36 ± 9.87 | 105.55 ± 44.16 | No | ||
Chen et al. 2012 China | 30 | 30 | 49.8 ± 10.8 | 50.4 ± 10.0 | 14/16 | 12/18 | VR | 12,000 U/Kg iv after anesthesia induction | Equivalent normal Saline | 102.5 ± 20.7 | 105.9 ± 20.2 | No | |
Oh et al. 2012 Korea | 30 | 30 | 67 ± 19 | 60 ± 12 | 20/10 | 16/14 | AVR | 1,000,000 U iv during surgery | Equivalent normal Saline | 99 ± 25 | 96 ± 22 | No | |
ONG et al. 2011 Korea | 24 | 24 | 51.9 ± 17.3 | 52.7 ± 18.9 | 8/16 | 9/15 | Aortic valve repair | 5000 U/Kg iv before CPB | Equivalent normal Saline | 164.3 ± 31.5 | 173.4 ± 28.4 | No | |
Zhou et al. 2010 China | 20 | 20 | 61.1 ± 8.7 | 28/12 | CABG | 15,000 U/Kg iv during surgery | Equivalent normal Saline | 83.5 ± 23.1 | 79.6 ± 25.7 | No | |||
Jiang et al. 2007 China | 15 | 15 | 57.4 ± 6.6 | 56.8 ± 6.1 | 11/9 | 11/9 | CABG | 1,000,000 U iv during surgery | Equivalent placebo | 108 ± 29 | 117 ± 34 | No | |
Nakanishi et al. 2006 Japan | 14 | 14 | 62 ± 9 | 61 ± 10 | 12/2 | 11/3 | CABG | 5000 U/Kg iv before aortic cannulation for CBP | Equivalent normal Saline | 150 ± 37 | 135 ± 39 | No |