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Table 1 Characteristics of the clinical trials included in the meta-analysis

From: The effect of Ulinastatin on postoperative course in cardiopulmonary bypass patients in Asia: a meta-analysis of randomized controlled trials

Reference, years, country of origin

Number of patients

Mean age

Gender (F/M)

Surgery

Interventions

CPB time (min)

Adverse effects

UTI group

Control group

UTI group

Control group

UTI group

Control group

UTI group

Control group

UTI group

Control group

Zhang et al. 2020 China

142

141

49.0 ± 14.3

50.3 ± 12.4

63/79

71/70

Open heart surgery

1,000,000 U iv, the half after anesthesia induction and the rest prime into CPB

Equivalent normal saline

102.87 ± 42.7

98.69 ± 47.76

No

Xu et al. 2017 China

20

20

53.4 ± 5.2

53.2 ± 5.1

12/8

13/7

Open heart surgery

5000 U/kg iv before CPB and at 1–3 days postoperatively

Equivalent normal saline

Unclear

No

Wang et al. 2016 China

36

30

48.4 ± 11.3

49.3 ± 11.7

32/4

26/4

AAR

300,000 U/8 h iv before 3 days postoperatively and 300,000 U/2 h during surgery

NR

228.6 ± 69.1

22.4 ± 62.5

No

Pang et al. 2015 China

30

30

53.5 ± 9.8

50.2 ± 9.1

15/15

21/9

Open heart surgery

5000 U/Kg iv after anesthesia induction

Equivalent normal Saline

215.3 ± 57.9

221.6 ± 76.1

No

Xu et al. 2013 China

18

18

54.8 ± 8.9

53.2 ± 7.3

16/2

15/3

AAR

20,000 U/Kg iv after anesthesia induction

Equivalent placebo

235.5 ± 25.9

247.2 ± 20.3

No

Hao et al. 2013 China

20

20

56.36 ± 10.81

54.27 ± 10.90

22/18

MVR, DVR, AVR

1000 U/Kg iv during the preoperative period

NR

98.36 ± 9.87

105.55 ± 44.16

No

Chen et al. 2012 China

30

30

49.8 ± 10.8

50.4 ± 10.0

14/16

12/18

VR

12,000 U/Kg iv after anesthesia induction

Equivalent normal Saline

102.5 ± 20.7

105.9 ± 20.2

No

Oh et al. 2012 Korea

30

30

67 ± 19

60 ± 12

20/10

16/14

AVR

1,000,000 U iv during surgery

Equivalent normal Saline

99 ± 25

96 ± 22

No

ONG et al. 2011 Korea

24

24

51.9 ± 17.3

52.7 ± 18.9

8/16

9/15

Aortic valve repair

5000 U/Kg iv before CPB

Equivalent normal Saline

164.3 ± 31.5

173.4 ± 28.4

No

Zhou et al. 2010 China

20

20

61.1 ± 8.7

28/12

CABG

15,000 U/Kg iv during surgery

Equivalent normal Saline

83.5 ± 23.1

79.6 ± 25.7

No

Jiang et al. 2007 China

15

15

57.4 ± 6.6

56.8 ± 6.1

11/9

11/9

CABG

1,000,000 U iv during surgery

Equivalent placebo

108 ± 29

117 ± 34

No

Nakanishi et al. 2006 Japan

14

14

62 ± 9

61 ± 10

12/2

11/3

CABG

5000 U/Kg iv before aortic cannulation for CBP

Equivalent normal Saline

150 ± 37

135 ± 39

No

  1. CBP = Cardiopulmonary Bypass; TAR = Total aortic arch replacement; AAR = Aortic Arch Replacement; VR = Valve Replacement, including Aortic Valve Replacement, Mitral Valve Replacement; MVR = Mitral Valve Replacement; DVR = Double (aortic and mitral) Valve Replacement; AVR = Aortic Valve Replacement; CABG = Coronary Artery Bypass Graft