Table 3 Histology and quantitative immunohistochemistry
From: Ascending aortic wall degeneration in patients with bicuspid versus tricuspid aortic valve
All patients | BAV | TAV | P value | |
|---|---|---|---|---|
Adventitial fibrosis | 0.2 ± 0.4 | 0.1 ± 0.3 | 0.2 ± 0.4 | 0.221 |
Medial fibrosis | 0.5 ± 1.1 | 0.1 ± 0.4 | 0.8 ± 1.4 | 0.016 |
Elastic fiber disorganization | 1.0 ± 1.0 | 0.8 ± 0.9 | 1.1 ± 1.1 | 0.191 |
Elastic fiber loss/fragmentation | 3.6 ± 1.4 | 3.3 ± 1.2 | 3.8 ± 1.6 | 0.206 |
Elastic fiber thinning | 1.1 ± 1.8 | 0.6 ± 1.4 | 1.6 ± 2.0 | 0.027 |
Laminar medial collapse | 0.6 ± 1.3 | 0.3 ± 0.9 | 0.8 ± 1.5 | 0.184 |
Classification of medial degeneration | 1.9 ± 0.8 | 1.7 ± 0.7 | 2.2 ± 0.8 | 0.045 |
Mucoid extracellular matrix accumulation | 4.6 ± 1.2 | 4.3 ± 0.9 | 4.9 ± 1.2 | 0.051 |
Smooth muscle cell disorganization | 0.6 ± 0.8 | 0.4 ± 0.7 | 0.8 ± 0.9 | 0.121 |
Smooth muscle cell nuclei loss | 2.8 ± 1.4 | 2.3 ± 1.5 | 3.2 ± 1.3 | 0.026 |
Medial thickness of vasa vasorum | 0.2 ± 0.4 | 0.3 ± 0.5 | 0.2 ± 0.4 | 0.407 |