Fig. 5

The permeability of blood–brain barrier increased in rats after CPB. Brain tissue is dyed blue by Evans blue, which crosses the blood–brain barrier (a). Bar graphs indicate the amount of Evans blue in brain tissue compared between the two groups (b). Bar graphs indicate the changes of Evans blue in brain tissue on the first day, the third day, and the seventh day after surgery (c). *P < 0.05 compared with SHAM group. CPB cardiopulmonary bypass; h hour, d day